Protective effect of Dl-3n-butylphthalide on learning and memory impairment induced by chronic intermittent hypoxia-hypercapnia exposure
| Autor: | Xin-long Huo, Ke-qin Chai, ling-yun Xiang, Yan-qing Qin, Bin Wu, Jing-jing Min, Lu Jin, Xiaotong Wang |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Drug Evaluation Preclinical Morris water navigation task Apoptosis Pharmacology CREB Neuroprotection Article Hypercapnia Rats Sprague-Dawley chemistry.chemical_compound Pulmonary Disease Chronic Obstructive Sirtuin 1 Memory Medicine Animals Hypoxia Brain Maze Learning Benzofurans Brain-derived neurotrophic factor Multidisciplinary biology business.industry Brain-Derived Neurotrophic Factor Mitochondrial Turnover TFAM Hypoxia (medical) Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Butylphthalide Rats Neuroprotective Agents Mitochondrial biogenesis chemistry Anesthesia biology.protein medicine.symptom business Transcription Factors |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Cognitive impairment is a common finding in patients with chronic obstructive pulmonary disease (COPD), but little attention has been focused on therapeutic intervention for this complication. Chronic intermittent hypoxia hypercapnia (CIHH) exposure is considered to be responsible for the pathogenesis of COPD. Dl-3n-Butylphthalide (NBP), extracted from Apium graveolens Linn, has displayed a broad spectrum of neuroprotective properties. Our study aimed to investigate the potential of NBP on CIHH-induced cognitive deficits. The cognitive function of rats after CIHH exposure was evaluated by the Morris water maze, which showed that the NBP treated group performed better in the navigation test. NBP activated BDNF and phosphorylated CREB, the both are responsible for neuroprotection. Additionally, NBP decreased CIHH induced apoptosis. Moreover, NBP further induced the expression of HIF-1α, accompanied by the up-regulation of the autophagy proteins Bnip3, Beclin-1 and LC3-II. Finally, NBP also reversed the decreased expression of SIRT1 and PGC-1α, but the expression of Tfam, Cox II and mtDNA remained unchanged. These results suggested that the neuroprotective effects of NBP under CIHH condition possibly occurred through the inhibition of apoptosis, promotion of hypoxia-induced autophagy, and activation of the SIRT1/PGC-1α signalling pathway, while stimulation of mitochondrial biogenesis may not be a characteristic response. |
| Databáze: | OpenAIRE |
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