Tumor invasion unit in gastric cancer revealed by QDs-based in situ molecular imaging and multispectral analysis
| Autor: | Chun-Wei Peng, Guifang Yang, Yan Li, Min Fang, Shu-Guang Yan, Hao-Liang Zhao, Jian-Ding Li, Wen-Qing Hu, Jingping Yuan |
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| Rok vydání: | 2014 |
| Předmět: |
Diagnostic Imaging
Male In situ Pathology medicine.medical_specialty Tumor Infiltrating Macrophages Biophysics Molecular imaging Tumor microenvironment of metastasis Bioengineering In Vitro Techniques Biology Metastasis Biomaterials Stomach Neoplasms medicine Overall survival Humans Aged Tumor microenvironment Quantum dots Tumor invasion unit Cancer Middle Aged medicine.disease Multispectral analysis Mechanics of Materials Cancer cell Ceramics and Composites Female Gastric cancer |
| Zdroj: | Biomaterials. 35:4125-4132 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/j.biomaterials.2014.01.059 |
| Popis: | In tumor tissues, cancer cells, tumor infiltrating macrophages and tumor neo-vessels in close spatial vicinity with one another form tumor invasion unit, which is a biologically important tumor microenvironment of metastasis to facilitate cancer invasion and metastasis. Establishing an in situ molecular imaging technology to simultaneously reveal these three components is essential for the in-depth investigation of tumor invasion unit. In this report, we have developed a computer-aided algorithm by quantum dots (QDs)-based multiplexed molecular imaging technique for such purpose. A series of studies on gastric cancer tumor tissues demonstrated that the tumor invasion unit was correlated with major unfavorable pathological features and worse clinical outcomes, which illustrated the significantly negative impacts and predictive power of tumor invasion unit on patient overall survival. This study confirmed the technical advantages of QDs-based in situ and simultaneous molecular imaging of key cancer molecules to gain deeper insights into the biology of cancer invasion. |
| Databáze: | OpenAIRE |
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