Influence of different dietary salts on the cardiovascular and renal effects of moxonidine in spontaneously hypertensive rats
| Autor: | Lena Malmberg, Heikki Vapaatalo, Hans-Jürgen Mest, Ilkka Pörsti, Terttu-Liisa Teräväinen, Kirsi Karjala, Ilari Paakkari, Eero Mervaala, Tuula Lähteenmäki, Heikki Karppanen |
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| Rok vydání: | 1997 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Sodium Drinking chemistry.chemical_element Blood Pressure Left ventricular hypertrophy Muscle Smooth Vascular Excretion Rats Sprague-Dawley chemistry.chemical_compound Heart Rate Internal medicine Rats Inbred SHR Renin–angiotensin system Renin medicine Animals Insulin Sodium Chloride Dietary Mesenteric arteries Aldosterone Antihypertensive Agents Pharmacology Moxonidine Body Weight Imidazoles General Medicine Organ Size medicine.disease Mesenteric Arteries Rats medicine.anatomical_structure Endocrinology Blood pressure chemistry Hypertension Hypertrophy Left Ventricular Salts medicine.drug Muscle Contraction |
| Zdroj: | Naunyn-Schmiedeberg's archives of pharmacology. 356(1) |
| ISSN: | 0028-1298 |
| Popis: | The influence of common salt (NaCl) and a novel potassium-, magnesium-, and L-lysine-enriched mineral salt on the cardiovascular and renal effects of the selective imidazoline I1-receptor agonist moxonidine was examined in spontaneously hypertensive rats (SHR). Common salt was added at the level of 6% of the dry weight of the chow, and mineral salt at a 75% higher level of 10.5% thereof to produce the same NaCl concentration of 6% as in the common salt group. During the control diet an 8-week oral treatment with moxonidine (117 mg/1000 g of the dry weight of the chow producing an approximate daily dose of 10 mg/kg), lowered blood pressure by 13 mmHg. The common salt diet alone raised blood pressure by 27 mmHg. Moxonidine lowered blood pressure by 21 mmHg during the common salt diet, but the blood pressure remained 19 mmHg higher than in the moxonidine-treated SHR receiving the control diet (P |
| Databáze: | OpenAIRE |
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