Electrophysiological scarring in remitted depressed patients: Elevated EEG functional connectivity between the posterior cingulate cortex and the subgenual prefrontal cortex as a neural marker for rumination
| Autor: | Hossein Shahabi, Diego A. Pizzagalli, Lars Benschop, Marie-Anne Vanderhasselt, Richard M. Leahy, Chris Baeken, Tasha Poppa, Takfarinas Medani |
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| Přispěvatelé: | Brain, Body and Cognition, Clinical sciences, Neuroprotection & Neuromodulation, Psychiatry, Faculty of Psychology and Educational Sciences |
| Rok vydání: | 2021 |
| Předmět: |
Prefrontal Cortex
Electroencephalography Gyrus Cinguli Functional connectivity Cicatrix 03 medical and health sciences 0302 clinical medicine Cortex (anatomy) Rumination Neural Pathways medicine Humans EEG Resting state Prefrontal cortex Default mode network Brain Mapping Depressive Disorder Major Remitted major depressive disorder medicine.diagnostic_test Resting state fMRI business.industry Brain Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Posterior cingulate Anxiety medicine.symptom business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Affective Disorders. 281:493-501 |
| ISSN: | 0165-0327 |
| Popis: | Introduction Prior resting state fMRI studies have revealed that elevated connectivity between the default mode network (DMN) and subgenual prefrontal cortex (sgPFC) connectivity may underly maladaptive rumination, which is a major risk factor for depression. To further evaluate such relationship, we investigated whether posterior regions of the DMN, showed elevated connectivity with the sgPFC in remitted depressed patients (rMDD) and whether this connectivity was related to maladaptive rumination. Methods We examined whether rMDD (N = 20) had elevated EEG posterior DMN – sgPFC functional connectivity when compared to age and sex matched healthy controls (N = 17), and whether this posterior DMN – sgPFC connectivity positively correlated with rumination. Using minimum norm as the source estimation method, we extracted current density maps from six regions of interest (ROIs) within the posterior DMN. EEG source-space functional connectivity was calculated using the Amplitude Envelope Correlation method. Results Relative to controls, rMDD showed increased posterior cingulate cortex (PCC) – sgPFC connectivity in the beta-3 (25–30 Hz) band. As hypothesized, PCC – sgPFC connectivity was positively associated with rumination for rMDD, even after controlling for depression and anxiety. Limitations The absence of an MDD patient group and the relatively small sample size can limit the generalizability of the results. Conclusions EEG resting state PCC – sgPFC functional connectivity is significantly elevated in rMDD and is associated with rumination, suggesting that EEG PCC – sgPFC connectivity may be useful as a neural marker to identify individuals at risk for depression. |
| Databáze: | OpenAIRE |
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