Notch as a tumour suppressor
Autor: | Freddy Radtke, Craig S. Nowell |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
General Mathematics Cellular differentiation Notch signaling pathway Context (language use) Biology medicine.disease_cause Bioinformatics law.invention 03 medical and health sciences law Neoplasms medicine Animals Humans Receptors Notch Tumor Suppressor Proteins Applied Mathematics Cancer Cell Differentiation medicine.disease Cell biology 030104 developmental biology Suppressor Stem cell Carcinogenesis Homeostasis Signal Transduction |
Zdroj: | Nature Reviews Cancer. 17:145-159 |
ISSN: | 1474-1768 1474-175X |
Popis: | The Notch signalling cascade is an evolutionarily conserved pathway that has a crucial role in regulating development and homeostasis in various tissues. The cellular processes and events that it controls are diverse, and continued investigation over recent decades has revealed how the role of Notch signalling is multifaceted and highly context dependent. Consistent with the far-reaching impact that Notch has on development and homeostasis, aberrant activity of the pathway is also linked to the initiation and progression of several malignancies, and Notch can in fact be either oncogenic or tumour suppressive depending on the tissue and cellular context. The Notch pathway therefore represents an important target for therapeutic agents designed to treat many types of cancer. In this Review, we focus on the latest developments relating specifically to the tumour-suppressor activity of Notch signalling and discuss the potential mechanisms by which Notch can inhibit carcinogenesis in various tissues. Potential therapeutic strategies aimed at restoring or augmenting Notch-mediated tumour suppression will also be highlighted. |
Databáze: | OpenAIRE |
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