Masculinization and reproductive effects in western mosquitofish (Gambusia affinis) after long-term exposure to androstenedione
| Autor: | Li Xin, Gui-Zhen Fang, Xue-Mei Cheng, Yang Yang, Jian-Liang Zhao, Li Yao, Guang-Guo Ying, Hu Shu, Liping Hou, Wen-Jun Shi |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Time Factors medicine.drug_class Health Toxicology and Mutagenesis media_common.quotation_subject medicine.medical_treatment Physiology 010501 environmental sciences 01 natural sciences Gambusia 03 medical and health sciences Cyprinodontiformes Internal medicine medicine Animals Body Size Androstenedione Gonads 0105 earth and related environmental sciences media_common Sex Characteristics biology Dose-Response Relationship Drug Reproduction Public Health Environmental and Occupational Health Embryo General Medicine Androgen biology.organism_classification Pollution Steroid hormone 030104 developmental biology Endocrinology Liver Androgens Female Development of the gonads Mosquitofish Water Pollutants Chemical |
| Zdroj: | Ecotoxicology and environmental safety. 147 |
| ISSN: | 1090-2414 |
| Popis: | Androstenedione (AED) is a naturally occurring steroid hormone. It is metabolized to potent androgens, which may induce androgenic effects in fish. However, little is known whether and how the androgens interfere with the fish gonadal development and reproduction. This study aimed at demonstrating the effects of long-term AED exposure on reproduction and development in mosquitofish ( Gambusia affinis ). The growth, development and several morphological endpoints, including the segment number and length of anal fin, histological changes of gonads and liver, were evaluated in mosquitofish during development from fertilized embryo to adulthood (180 days) after exposure of AED at environmentally relevant concentrations. We found that the growth (length, body weight and condition factor) of fish was negatively correlated with AED concentration in females, but not in males. The significant elongation of the ray and increment of segment numbers in the anal fin, were detected in all mosquitofish after exposure. Moreover, AED exposure (0.4gµ/L) caused damages in gonads and reduced the number of pregnant females. These findings indicate that AED has adverse effects on the growth and development of the western mosquitofish after long-term exposure (180d). Long-term exposure (180d) to AED, including environmentally relevant concentration (0.4 µg/L and 4 µg/L), induced masculinization in female mosquitofish under the experimental conditions. |
| Databáze: | OpenAIRE |
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