Ferroptosis: At the Crossroad of Gemcitabine Resistance and Tumorigenesis in Pancreatic Cancer
| Autor: | Jin Xu, Chen Liang, Jiang Liu, Jianhui Yang, Jie Hua, Qingcai Meng, Wei Wang, Xianjun Yu, Bo Zhang, Zhen Tan, Si Shi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Programmed cell death
QH301-705.5 pancreatic ductal adenocarcinoma Drug resistance Review medicine.disease_cause Deoxycytidine Catalysis NRF2 Inorganic Chemistry Pancreatic cancer Medicine Humans Biology (General) Physical and Theoretical Chemistry QD1-999 Molecular Biology Survival rate Spectroscopy chemistry.chemical_classification Reactive oxygen species gemcitabine resistance business.industry Ferroptosis Organic Chemistry ROS General Medicine medicine.disease Phospholipid Hydroperoxide Glutathione Peroxidase Gemcitabine ferroptosis Computer Science Applications Pancreatic Neoplasms Chemistry MicroRNAs chemistry Drug Resistance Neoplasm Cancer research business Carcinogenesis Reactive Oxygen Species medicine.drug Carcinoma Pancreatic Ductal Signal Transduction |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 10944, p 10944 (2021) |
| ISSN: | 1422-0067 |
| Popis: | The overall five-year survival rate of pancreatic cancer has hardly changed in the past few decades (less than 10%) because of resistance to all known therapies, including chemotherapeutic drugs. In the past few decades, gemcitabine has been at the forefront of treatment for pancreatic ductal adenocarcinoma, but more strategies to combat drug resistance need to be explored. One promising possibility is ferroptosis, a form of a nonapoptotic cell death that depends on intracellular iron and occurs through the accumulation of lipid reactive oxygen species, which are significant in drug resistance. In this article, we reviewed gemcitabine-resistance mechanisms; assessed the relationship among ferroptosis, tumorigenesis and gemcitabine resistance, and explored a new treatment method for pancreatic cancer. |
| Databáze: | OpenAIRE |
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