Low Risk of Irritable Bowel Syndrome after Clostridium difficile Infection
| Autor: | Fernand Girard Pipau, Xavier Hébuterne, Raffaella Dainese, Geoffroy Vanbiervliet, Stephen M. Collins, Thierry Piche, Patrick Rampal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
Risk medicine.medical_specialty Gastroenterology Irritable Bowel Syndrome Feces Surveys and Questionnaires Internal medicine Epidemiology medicine Humans lcsh:RC799-869 Irritable bowel syndrome Aged Aged 80 and over Clostridioides difficile business.industry Incidence Incidence (epidemiology) Age Factors Immunity General Medicine Middle Aged Clostridium difficile medicine.disease Surgery Metronidazole Clostridium Infections Vomiting Population study Female Original Article lcsh:Diseases of the digestive system. Gastroenterology medicine.symptom business medicine.drug |
| Zdroj: | Canadian Journal of Gastroenterology, Vol 21, Iss 11, Pp 727-731 (2007) |
| ISSN: | 0835-7900 |
| Popis: | OBJECTIVE: The incidence of postinfectious irritable bowel syndrome (IBS) ranges between 4% and 32% of individuals after bacterial or parasitic infection. This study analyzed IBS symptoms in hospitalized patients three months after a symptomaticClostridium difficileinfection.PATIENTS AND METHODS: All patients with a proven, symptomaticC difficileinfection identified in the department of bacteriology over a four-month period were considered for enrolment. Patients were excluded in cases of pre-existing IBS or other organic gastrointestinal diseases. Patients completed both modified Talley and Rome II questionnaires within five days of clinical improvement with metronidazole and at three months postinfection, when stools were cultured andC difficiletoxins were examined to exclude ongoing infection.RESULTS: Twenty-three patients were evaluated three months after infection withC difficile. Just after infection, 15 patients were symptom free, whereas eight patients exhibited symptoms suggestive of IBS. Three months after infection, 22 patients remained symptom free, whereas one patient presented with symptoms indicative of IBS. That female patient had a prolonged infection without vomiting.CONCLUSIONS: We have shown that while transient functional bowel disorder occurred in 34.7% of patients (eight of 23 patients) recently infected withC difficile, only 4.3% of patients (one of 23 patients) had symptoms indicative of IBS after three months (ie, postinfectious IBS). Because an age-related reduction in immune responsiveness has been documented, it can be speculated that the low incidence of postinfectious IBS may be explained by the older age of the study population. Therefore, it cannot be excluded that the findings may be different in younger patients. |
| Databáze: | OpenAIRE |
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