Varicella zoster virus reactivation antedating ipsilateral brainstem stroke
| Autor: | Giuliana Galassi, Marcella Malagoli, Maurilio Genovese, Marisa Meacci |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Herpesvirus 3 Human medicine.medical_specialty Brain Stem Infarctions Acyclovir Dermatology Antibodies Viral medicine.disease_cause Antiviral Agents 03 medical and health sciences 0302 clinical medicine Blurred vision Pons medicine Humans pontine stroke cervical rash ophthalmic zoster vertebrobasilar circulation Optic neuritis Vascular Diseases 030212 general & internal medicine Stroke Aged medicine.diagnostic_test business.industry Varicella zoster virus Magnetic resonance imaging General Medicine Hypoesthesia medicine.disease Magnetic Resonance Imaging Dysphagia Ophthalmic zoster Herpes Zoster Ophthalmicus varicella zoster reactivation viral spread Female Virus Activation medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Galassi, Giuliana; Genovese, Maurilio; Meacci, Marisa; & Malagoli, Marcella. (2018). Varicella zoster virus reactivation antedating ipsilateral brainstem stroke. Dermatology Online Journal, 24(8). Retrieved from: http://www.escholarship.org/uc/item/4gj9h9jf |
| ISSN: | 1087-2108 |
| DOI: | 10.5070/d3248041133 |
| Popis: | itor Title: Varicella zoster virus reactivation antedating ipsilateral brainstem stroke Authors: Giuliana Galassi1, Maurilio Genovese2, Marisa Meacci3, Marcella Malagoli2 Affiliations: 1Department of Biomedical, Metabolic, Neural Sciences, University Hospital of Modena, Italy, 2Neuroradiology Service, University Hospital of Modena, Italy, 3Department of Laboratory Medicine and Patholgy, Microbiology and Virology Unit, University Hospital of Modena, Italy Corresponding Author: Giuliana Galassi, MD, Department of Biomedical, Metabolic, Neural Sciences, University Hospital of Modena, Via P. Giardini 1455, Modena, Italy, Tel: 39-3497325802, Email: giulianagalassi46@gmail.com Abstract: Varicella zoster virus (VZV) infection and reactivation are associated with a number of neurologic conditions. Unifocal large vessel infarcts may follow zoster in the trigeminal or cervical distribution as a result of transaxonal transport of virus from trigeminal or cervical afferent fibers that innervate vessels. Ophthalmic zoster (HZO) might cause ophthalmoplegic syndromes, with secondary optic neuritis. Mechanisms include local orbital muscle inflammation and, viral spread from the ophthalmic branch of the fifth nerve with associated vasculopathy. A 72-year-old man developed a vesicular rash in the territory of C5-T5-6. Within four weeks, the patient developed headache, dysphagia, left facial and extremity ataxic weakness. Magnetic resonance imaging (MRI) revealed a right pontine infarction. A 66-year-old woman presented with right-sided painfull HZO. One week later she developed complete external ophthalmoplegia and blurred vision. MRI showed ill-defined signal alteration in the retrobulbar tissue. Three weeks later, the patient was admitted because of dysarthria, deviated tongue, left-sided limb weakness, and tactile hypoesthesia. Spinal fluid contained 23 lymphocytes/mm3 and increased protein. The serum contained antibodies to VZV IgG and IgM in both cases. The patients received intravenously acyclovir with improvement. This report confirms unusual occurrence of ipsilateral brainstem stroke after VZV reactivation in immunocompetent subjects. |
| Databáze: | OpenAIRE |
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