Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer’s Disease

Autor:	Yi Sun, Lijuan Xu, Hongming Shao, Danni Quan, Zixin Mo, Jue Wang, Wannian Zhang, Jianqiang Yu, Chunlin Zhuang, Ke Xu
Rok vydání:	2022
Předmět:	Mice Alzheimer Disease Receptor-Interacting Protein Serine-Threonine Kinases Necroptosis Drug Discovery Animals Humans Molecular Medicine Apoptosis Cyclopentanes Benzothiazoles
Zdroj:	Journal of Medicinal Chemistry. 65:14957-14969
ISSN:	1520-4804 0022-2623
DOI:	10.1021/acs.jmedchem.2c01478
Popis:	Receptor-interacting protein kinase 1 (RIPK1) contributes to a broad set of inflammations and necroptosis in human diseases, which also plays an important role in the pathogenesis of Alzheimer's disease (AD). The inhibition of RIPK1 could be a novel strategy to improve cognitive function.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de87262650f9d185feac1a95a0b0f7a https://doi.org/10.1021/acs.jmedchem.2c01478 Zobrazit plný text záznamu