Stability of ondansetron hydrochloride injection in various beverages
| Autor: | Weeranuj Yamreudeewong, Satyavijayan Narasimhan Danthi, Ronald A. Hill, Janet L. Fox |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.drug_class
Drug Storage Carbonated Beverages Pharmacology Beverages Ondansetron Drug Stability medicine Chemical Precipitation Humans Antiemetic Chromatography High Pressure Liquid Ondansetron hydrochloride Chromatography Tea Chemistry Health Policy Temperature food and beverages Free base Anti-Anxiety Agents FRUIT PUNCH Antipsychotic Agents medicine.drug |
| Zdroj: | American Journal of Health-System Pharmacy. 52:2011-2014 |
| ISSN: | 1535-2900 1079-2082 |
| DOI: | 10.1093/ajhp/52.18.2011 |
| Popis: | The stability of ondansetron hydrochloride injection in beverages likely to be acceptable to patients was studied. Ondansetron hydrochloride injection (containing ondansetron 2 mg/mL) was added to apple juice, fruit punch, cherry-flavored drink, carbonated soft drinks, and hot tea to provide a nominal ondansetron concentration of 32.8, 64.5, or 95.2 micrograms/mL. Samples were stored at -3 to 28 degrees C (noncarbonated-beverage mixtures except tea), 2 to 28 degrees C (carbonated-beverage mixtures), and 25 degrees C (tea) and assayed for ondansetron concentration by high-performance liquid chromatography at 6, 24, 48, and 72 hours (noncarbonated-beverage mixtures except tea); 6, 24, and 48 hours (carbonated-beverage mixtures); and 1 hour (tea). More than 95% of the initial ondansetron concentration was retained in apple juice, fruit punch, cherry-flavored drink, Sprite, and Diet Coke throughout the periods studied. A precipitate formed immediately after ondansetron was added to hot tea, but the drug was chemically stable for at least one hour in this preparation. Ondansetron hydrochloride injection 32.7, 64.5, and 95.2 micrograms/mL (expressed as free base) was stable in various beverages when stored at -3 to 28 degrees C for up to 72 hours. Ondansetron at these same concentrations precipitated in hot tea preparations but was chemically stable for at least one hour. |
| Databáze: | OpenAIRE |
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