Untargeted lipidomics using liquid chromatography-ion mobility-mass spectrometry reveals novel triacylglycerides in human milk
| Autor: | Alexandra D. George, Melvin C. L. Gay, Mary E. Wlodek, Robert D. Trengove, Kevin Murray, Donna T. Geddes |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Breastfeeding lcsh:Medicine Breast milk 01 natural sciences Article Workflow 03 medical and health sciences chemistry.chemical_compound Eating Lactation Lipidomics medicine Humans lcsh:Science Triglycerides chemistry.chemical_classification 030109 nutrition & dietetics Multidisciplinary Chromatography Milk Human Mass spectrometry lcsh:R 010401 analytical chemistry Fatty acid Infant Lipidome Lauric acid 0104 chemical sciences medicine.anatomical_structure Breast Feeding chemistry lcsh:Q Female Breast feeding Chromatography Liquid |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) |
| ISSN: | 2045-2322 |
| Popis: | Human milk provides the infant with the essential nutritive and non-nutritive factors required for health, growth and development. The human milk lipidome is complex, but comprises predominantly triacylglycerides. Historically, the fatty acid profile of the entire human milk lipidome has been investigated, and many relationships have been identified between infant health and fatty acids. Most of these fatty acids are, however, delivered to the infant as triacylglycerides. Using liquid chromatography-ion mobility-mass spectrometry, the objective of this study was to characterise the triacylglyceride profile of human milk and elucidate relationships between the triacylglyceride profile and infant outcomes in a cohort of 10 exclusively breastfeeding woman-infant dyads. 205 triacylglycerides were identified, including 98 previously not reported in human milk. The dose of specific triacylglycerides differed in relation to infant health, such as lauric acid containing TAGs, which were delivered in significantly higher dose to healthy infants compared to unwell infants. |
| Databáze: | OpenAIRE |
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