In uteroexposure to selective serotonin reuptake inhibitors and development of mental disorders: a systematic review and meta‐analysis

Autor: Annemette Halvorsen, Søren Dinesen Østergaard, Benedikte Hesel, Andreas A. Danielsen
Rok vydání: 2019
Předmět:
medicine.medical_specialty
second-generation
Autism Spectrum Disorder
PsycINFO
antidepressive agents
03 medical and health sciences
0302 clinical medicine
prenatal exposure delayed effects
Pregnancy
Internal medicine
PRENATAL ANTIDEPRESSANT EXPOSURE
medicine
SSRI
Humans
serotonin uptake inhibitors
RISK
OUTCOMES
Depressive Disorder
Evidence-Based Medicine
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
business.industry
AUTISM SPECTRUM DISORDER
HYPERACTIVITY DISORDER
PSYCHIATRIC-DISORDERS
Hazard ratio
Guideline
DEPRESSION
medicine.disease
Confidence interval
mental disorders
030227 psychiatry
Pregnancy Complications
Psychiatry and Mental health
PREGNANCY
Systematic review
Attention Deficit Disorder with Hyperactivity
In utero
Autism spectrum disorder
Prenatal Exposure Delayed Effects
Meta-analysis
Female
business
Selective Serotonin Reuptake Inhibitors
030217 neurology & neurosurgery
Zdroj: Halvorsen, A, Hesel, B, Østergaard, S D & Danielsen, A A 2019, ' In utero exposure to selective serotonin reuptake inhibitors and development of mental disorders : A Systematic Review and Meta-analysis ', Acta Psychiatrica Scandinavica, vol. 139, no. 6, pp. 493-507 . https://doi.org/10.1111/acps.13030
ISSN: 1600-0447
0001-690X
DOI: 10.1111/acps.13030
Popis: Objective: Several studies have investigated whether in utero exposure to selective serotonin reuptake inhibitors (SSRIs) is associated with increased risk of developing mental or behavioural disorders. The aim of this study was to perform a systematic review and meta-analysis based on this literature. Methods: A systematic search of eligible literature in PubMed, EMBASE, and PsycINFO and subsequent meta-analysis was conducted in adherence with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guideline. Results: A total of 20 studies were included in the review, and results from 18 of these were meta-analyzed. We found a statistically significant positive association between in utero exposure to SSRIs and mental or behavioural disorders such as autism spectrum disorder (hazard ratio (HR) = 1.27; 95% confidence interval (CI) = 1.10–1.47), attention-deficit/hyperactivity disorder (HR = 1.33; 95% CI = 1.06–1.66) and mental retardation (HR = 1.41; 95% CI = 1.03–1.91). Confounding by indication was identified in five of seven studies investigating this aspect. Conclusion: Exposure to SSRIs in utero is associated with increased risk of developing mental or behavioural disorders. However, these associations do not necessarily reflect a causal relationship since the results included in this meta-analysis are likely affected by residual confounding by indication, which is likely to account for some (or all) of the positive association.
Databáze: OpenAIRE
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