Synaptic communication mediates the assembly of a self-organizing circuit that controls reproduction
| Autor: | Jonathan Boulanger-Weill, Agnès O. Martin, Pierre Fontanaud, Lian Hollander-Cohen, T. Fiordelisio-Coll, Adèle Faucherre, Patrice Mollard, Matan Golan, D. Gajbhiye, A. Pinot |
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| Přispěvatelé: | Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Institute of Animal Science - Israel, Harvard University [Cambridge], BioCampus Montpellier (BCM), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), The Hebrew University of Jerusalem (HUJ), Universidad Nacional Autónoma de México (UNAM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), BioCampus (BCM), Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), Guerineau, Nathalie C. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cell signaling
endocrine system media_common.quotation_subject [SDV]Life Sciences [q-bio] Biology 03 medical and health sciences Glutamatergic 0302 clinical medicine Developmental Neuroscience Zebrafish larvae [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Research Articles 030304 developmental biology media_common 0303 health sciences Multidisciplinary SciAdv r-articles Life Sciences [SDV] Life Sciences [q-bio] nervous system Initial phase Nasal placode [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Reproduction Neuroscience 030217 neurology & neurosurgery hormones hormone substitutes and hormone antagonists Research Article |
| Zdroj: | Science Advances Science Advances, American Association for the Advancement of Science (AAAS), 2021, 7 (8), pp.eabc8475. ⟨10.1126/sciadv.abc8475⟩ Science Advances, 2021, 7 (8), pp.eabc8475. ⟨10.1126/sciadv.abc8475⟩ |
| ISSN: | 2375-2548 |
| Popis: | Migration of GnRH neurons, a critical step for vertebrate reproduction, depends on circuit-intrinsic synaptic communication. Migration of gonadotropin-releasing hormone (GnRH) neurons from their birthplace in the nasal placode to their hypothalamic destination is critical for vertebrate reproduction and species persistence. While their migration mode as individual GnRH neurons has been extensively studied, the role of GnRH-GnRH cell communication during migration remains largely unexplored. Here, we show in awake zebrafish larvae that migrating GnRH neurons pause at the nasal-forebrain junction and form clusters that act as interhemisphere neuronal ensembles. Within the ensembles, GnRH neurons create an isolated, spontaneously active circuit that is internally wired through monosynaptic glutamatergic synapses into which newborn GnRH neurons integrate before entering the brain. This initial phase of integration drives a phenotypic switch, which is essential for GnRH neurons to properly migrate toward their hypothalamic destination. Together, these experiments reveal a critical step for reproduction, which depends on synaptic communication between migrating GnRH neurons. |
| Databáze: | OpenAIRE |
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