Studies on Obtaining and Characterization a Pregabalin-cyclodextrin Complex for Taste Masking Purpose
| Autor: | Olimpia Dumitriu Buzia, Carmen Gafitanu, Liliana Tartau, Oana Maria Dragostin, Lenuta Profire, Gratiela Eliza Popa |
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| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Cyclodextrin Process equipment 010405 organic chemistry Chemistry Materials Science (miscellaneous) Process Chemistry and Technology General Engineering Pregabalin 02 engineering and technology General Chemistry General Medicine 021001 nanoscience & nanotechnology 01 natural sciences General Biochemistry Genetics and Molecular Biology 0104 chemical sciences Characterization (materials science) Petrochemistry Materials Chemistry medicine Organic chemistry Taste masking General Pharmacology Toxicology and Pharmaceutics 0210 nano-technology medicine.drug |
| Zdroj: | Web of Science |
| ISSN: | 2668-8212 0034-7752 |
| Popis: | Pregabalin is an anticonvulsant and analgesic drug that stirs more and more the interest of the researchers. Its stability, solubility and taste can be modified by obtaining complexes with cyclodextrins. For this purpose, in the present study betacyclodextrin and hydroxypropyl-betacyclodextrin were included. The obtaining of inclusion complexes was confirmed by ATR-FTIR spectroscopy and UV spectroscopy. The results demonstrated that it is possible to develop inclusion complexes of pregabalin with betacyclodextrin and hydroxypropyl-betacyclodextrin, with moderate efficiency. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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