Consequences of knocking out BMP signaling in the mouse
| Autor: | Guang-Quan Zhao |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Mice
Knockout Genetics animal structures Embryogenesis Gene Expression Regulation Developmental Mutagenesis (molecular biology technique) Organogenesis Cell Biology Biology Bone morphogenetic protein BMPR2 Cell biology Gastrulation Embryonic and Fetal Development Mice Endocrinology Bone Morphogenetic Proteins embryonic structures Mesoderm formation Animals Limb development Signal Transduction |
| Zdroj: | genesis. 35:43-56 |
| ISSN: | 1526-968X 1526-954X |
| DOI: | 10.1002/gene.10167 |
| Popis: | During the past two decades, a significant amount of data has been accumulated revealing the intriguing functions of bone morphogenetic proteins (BMPs) in all aspects of embryonic development and organogenesis. Numerous genes encoding BMPs, BMP receptors, and their downstream signal transducers have been mutated in the mouse through targeted mutagenesis. This review focuses on what is known about the role of BMP signaling in gastrulation, mesoderm formation, left-right asymmetry, neural patterning, skeletal and limb development, organogenesis, and gametogenesis as revealed by BMP-signaling mutants. |
| Databáze: | OpenAIRE |
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