Radioimmunodetection of colorectal carcinoma with 111In-labelled monoclonal antibody IVP ZCE 025 (a tissue culture-produced anti-CEA MAb)
| Autor: | Nancy H. Evans, Him-Wing Chan, Ralph J. Doerr, Hani Abdel-Nabi, Schweighardt S, Farrell Ee, Jayakumari M. Gona, Balu D |
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| Rok vydání: | 1994 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty medicine.drug_class Colorectal cancer Monoclonal antibody Gastroenterology Tissue culture Internal medicine Radioimmunodetection medicine Humans Radiology Nuclear Medicine and imaging In patient Overall performance Prospective Studies Prospective cohort study Aged Aged 80 and over business.industry Indium Radioisotopes General Medicine Middle Aged medicine.disease True negative Female business Colorectal Neoplasms |
| Zdroj: | Nuclear medicine communications. 15(2) |
| ISSN: | 0143-3636 |
| Popis: | The aims of this prospective, nonrandomized phase I/II study were to evaluate (1) the safety and (2) the detection rate of tissue culture-derived, 111In-labelled anti-CEA monoclonal antibody IVP ZCE 025 in patients with primary, metastatic and occult colorectal carcinomas. 111In-IVP ZCE 025 imaging correctly identified 31 of 37 primary colorectal carcinomas, 10 of 19 hot liver metastases, 11 of 16 distant metastases and seven of seven local tumour recurrences. Previously unsuspected tumours were detected by IVP ZCE 025 imaging in 11 of 34 patients. The scans were also true negative in four patients. The overall performance characteristics of IVP ZCE 025 at monoclonal antibody doses of 1.0-5.0 mg were comparable to those obtained with 40.0 mg ascites-produced ZCE 025. No clinical or biochemical adverse reactions were encountered in the 61 patients entered into this study. |
| Databáze: | OpenAIRE |
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