Opposing Associations of NT-proBNP With Risks of Diabetes and Diabetes-Related Complications
| Autor: | Matthias B. Schulze, Fabian Eichelmann, Olga Kuxhaus, Anna Birukov, Elli Polemiti, Heiner Boeing, Andreas Fritsche, Janine Wirth, Cornelia Weikert |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Diabetes risk Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Type 2 diabetes Diabetes Complications 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus Natriuretic Peptide Brain Internal Medicine medicine Humans Prospective Studies 030212 general & internal medicine Prospective cohort study Aged Heart Failure Advanced and Specialized Nursing business.industry Hazard ratio Confounding Middle Aged medicine.disease Peptide Fragments European Prospective Investigation into Cancer and Nutrition Diabetes Mellitus Type 2 Cardiovascular Diseases Cohort Female business Biomarkers |
| Zdroj: | Diabetes Care. 43:2930-2937 |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/dc20-0553 |
| Popis: | OBJECTIVE Circulating N-terminal pro B-type natriuretic peptide (NT-proBNP) is a classic diagnostic and prognostic marker for heart failure. However, it is inversely associated with diabetes risk. We aimed to investigate relationships of NT-proBNP with risk of diabetes-related complications in initially healthy individuals. RESEARCH DESIGN AND METHODS We performed a case-cohort study within the European Prospective Investigation Into Cancer and Nutrition (EPIC)-Potsdam cohort including a random subcohort (n = 1,294) and incident cases of type 2 diabetes (n = 649) and cardiovascular diseases (n = 478). Incident cases of type 2 diabetes (n = 545) were followed up for microvascular (n = 133) and macrovascular (n = 50) complications. Plasma NT-proBNP was measured at baseline in initially healthy participants. RESULTS In multivariable models, NT-proBNP was linearly inversely associated with incident type 2 diabetes with a hazard ratio (HR) (95% CI) per doubling in NT-proBNP of 0.91 (0.86, 0.98). The association was only observable in women (0.80 [0.72, 0.90]) compared with men (0.98 [0.91, 1.07]). Among people with incident diabetes, NT-proBNP was positively associated with diabetes complications: overall, 1.31 (1.13, 1.53); microvascular complications, 1.20 (1.01, 1.43); and macrovascular complications, 1.37 (1.03, 1.83). CONCLUSIONS Although higher NT-proBNP levels are associated with lower diabetes risk, NT-proBNP is a biomarker for vascular complications in people who develop diabetes independent of potential confounders. Thus, NT-proBNP might be informative to monitor risk for diabetes-related microvascular and macrovascular complications, which should be further explored in future prospective studies. |
| Databáze: | OpenAIRE |
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