Hot-Melt 3D Extrusion for the Fabrication of Customizable Modified-Release Solid Dosage Forms

Autor:	Song Sang-Byeong, Jaemin Lee, Yun-Seok Rhee, Inhwan Noh, Song Chan-Woo
Rok vydání:	2020
Předmět:	Materials science lcsh:RS1-441 Pharmaceutical Science Polyethylene glycol Article Dosage form lcsh:Pharmacy and materia medica chemistry.chemical_compound personalized medication Solubility Dissolution ibuprofen solid dispersion chemistry.chemical_classification hot-melt extrusion 3D printing Polymer immediate release Controlled release Amorphous solid chemistry Chemical engineering Extrusion controlled release polyvinyl pyrrolidone pharmaceutical manufacturing solubilization
Zdroj:	Pharmaceutics, Vol 12, Iss 738, p 738 (2020) Pharmaceutics Volume 12 Issue 8
ISSN:	1999-4923
DOI:	10.3390/pharmaceutics12080738
Popis:	In this work, modified-release solid dosage forms were fabricated by adjusting geometrical properties of solid dosage forms through hot-melt 3D extrusion (3D HME). Using a 3D printer with air pressure driving HME system, solid dosage forms containing ibuprofen (IBF), polyvinyl pyrrolidone (PVP), and polyethylene glycol (PEG) were printed by simultaneous HME and 3D deposition. Printed solid dosage forms were evaluated for their physicochemical properties, dissolution rates, and floatable behavior. Results revealed that IBF content in the solid dosage form could be individualized by adjusting the volume of solid dosage form. IBF was dispersed as amorphous state with enhanced solubility and dissolution rate in a polymer solid dosage form matrix. Due to absence of a disintegrant, sustained release of IBF from printed solid dosage forms was observed in phosphate buffer at pH 6.8. The dissolution rate of IBF was dependent on geometric properties of the solid dosage form. The dissolution rate of IBF could be modified by merging two different geometries into one solid dosage form. In this study, the 3D HME process showed high reproducibility and accuracy for preparing dosage forms. API dosage and release profile were found to be customizable by modifying or combining 3D modeling.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ddf3de0926cbfed9ca2a9837bfe9654 https://doi.org/10.3390/pharmaceutics12080738 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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