Correlation of maternal serum fetuin/alpha2-HS-glycoprotein concentration with maternal insulin resistance and anthropometric parameters of neonates in normal pregnancy and gestational diabetes
| Autor: | Margit Kovács, Zsolt Melczer, László Kalabay, György Siller, Attila Pajor, Károly Cseh, Gábor Winkler, Gábor Speer, Éva Baranyi, István Karádi, György M Csákány |
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| Rok vydání: | 2002 |
| Předmět: |
Blood Glucose
Leptin medicine.medical_specialty Cephalometry alpha-2-HS-Glycoprotein Endocrinology Diabetes and Metabolism medicine.medical_treatment Gestational Age Endocrinology Insulin resistance Pregnancy Internal medicine Diabetes mellitus medicine Humans C-Peptide Tumor Necrosis Factor-alpha business.industry Insulin Body Weight Infant Newborn Gestational age Blood Proteins General Medicine medicine.disease Body Height Gestational diabetes Diabetes Gestational Female Insulin Resistance business alpha-2-HS-glycoprotein |
| Zdroj: | European Journal of Endocrinology. :243-248 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje.0.1470243 |
| Popis: | OBJECTIVE: Human fetuin/alpha(2)-HS-glycoprotein (AHSG) is a 49 kDa serum and tissue protein which is a natural inhibitor of insulin receptor signaling. We investigated serum AHSG levels during pregnancy and whether the protein is involved in insulin resistance observed in healthy pregnant women and patients with gestational diabetes. DESIGN: One hundred and four healthy pregnant women and 23 of their neonates, 30 patients with gestational diabetes and their neonates and 30 healthy age-matched non-pregnant females as a control group were investigated in a case-control cross-sectional study. METHODS: Serum AHSG was determined by radial immunodiffusion. RESULTS: We observed an increase of serum AHSG concentration in the second and third trimesters. Gestational diabetes patients had significantly higher AHSG levels than healthy pregnant women and non-pregnant controls. There was a highly significant positive correlation between serum AHSG concentration and indirect parameters of insulin resistance, i.e. tumor necrosis factor-alpha (TNF-alpha), leptin, C-peptide and C-peptide/blood glucose ratio. There was also a negative correlation between maternal AHSG, TNF-alpha, leptin levels and head circumference, body length and body weight of newborns. CONCLUSION: AHSG, TNF-alpha and leptin may contribute to insulin resistance during normal pregnancy and gestational diabetes. AHSG along with these cytokines may also negatively regulate neonatal skeletal development. |
| Databáze: | OpenAIRE |
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