Corrigendum to 'Chromosome 3 cluster rs11385942 variant links complement activation with severe COVID-19' [J. Autoimmun. 117C (2020) 102595]
| Autor: | Pier Luigi Meroni, Francesco Malvestiti, Luigia Scudeller, Samantha Griffini, Elena Grovetti, Giuseppe Lamorte, Luca Valenti, Massimo Cugno, Flora Peyvandi, Daniele Prati, Alessandra Bandera, Sara Colonia Uceda Renteria |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Risk 2019-20 coronavirus outbreak Genotype Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Immunology Complement C5a Computational biology Biology Disease cluster Polymorphism Single Nucleotide Article White People ABO Blood-Group System Gene Frequency Humans Immunology and Allergy Genetic Predisposition to Disease Complement Activation Genetic Association Studies Aged SARS-CoV-2 COVID-19 Middle Aged Viral Load Complement system Hospitalization Chromosome 3 Multigene Family Disease Progression Female Chromosomes Human Pair 3 |
| Zdroj: | Journal of Autoimmunity BASE-Bielefeld Academic Search Engine |
| ISSN: | 0896-8411 |
| Popis: | Genetic variation at a multigene cluster at chromosome 3p21.31 and the ABO blood group have been associated with the risk of developing severe COVID-19, but the mechanism remains unclear. Complement activation has been associated with COVID-19 severity.The aim of this study was to examine whether chromosome 3p21.31 and the ABO variants are linked to the activation of the complement cascade in COVID-19 patients.We considered 72 unrelated European hospitalized patients with genetic data and evaluation of circulating C5a and soluble terminal complement complex C5b-9 (SC5b-9). Twenty-six (36.1%) patients carried the rs11385942 GGA variant and 44 (66.1%) non-O blood group associated with increased risk of severe COVID-19.C5a and SC5-b9 plasma levels were higher in rs11385949 GA carriers than in non-carriers (P = 0.041 and P = 0.012, respectively), while C5a levels were higher in non-O group than in O group patients (P = 0.019). The association between rs11385949 and SC5b-9 remained significant after adjustment for ABO and disease severity (P = 0.004) and further correction for C5a (P = 0.018). There was a direct relationship between upper airways viral load and SC5b-9 in carriers of the rs11385949 risk allele (P = 0.032), which was not observed in non-carriers.The rs11385949 GGA variant, tagging the chromosome 3 gene cluster variation and predisposing to severe COVID-19, is associated with enhanced complement activation, both with C5a and terminal complement complex, while non-O blood group with C5a levels. These findings provide a link between genetic susceptibility to more severe COVID-19 and complement activation. |
| Databáze: | OpenAIRE |
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