Contribution of nasal biopsy to leprosy diagnosis
| Autor: | José Antônio Patrocínio, Antonio Diniz Souza, Isabela Maria Bernardes Goulart, Lucas Gomes Patrocinio, Raul Negrao Fleury, Flavia Marques Naves Mota, M.M. Naves |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Adolescent Biopsy Mucous membrane of nose Tuberculoid leprosy Severity of Illness Index Predictive Value of Tests Leprosy otorhinolaryngologic diseases medicine Immunology and Allergy Humans Child Nose Aged Skin Aged 80 and over Lepromatous leprosy medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease Dermatology Mycobacterium leprae Nasal Mucosa medicine.anatomical_structure Early Diagnosis Otorhinolaryngology Skin biopsy Disease Progression Histopathology business |
| Zdroj: | American journal of rhinologyallergy. 23(2) |
| ISSN: | 1945-8924 |
| Popis: | Background The nasal mucosa plays the main role as the entry and the exit of leprosy bacilli and the nasal involvement may precede the skin lesions by several years. Nasal biopsy has been used in research but its clinical application has not been described. We evaluated the contribution of the nasal biopsy for the diagnosis of leprosy and its correlation to skin biopsy and skin smear in untreated patients. Methods We evaluated changes in nasal biopsy in 227 leprosy patients. Patients were clinically classified and skin and nasal biopsies and skin smear were performed. Results Nasal biopsy showed positivity in 100% of the lepromatous spectrum decreasing toward the tuberculoid (TT) pole. Patients with TT or indeterminate forms did not present any nasal alterations, showing that they are the true paucibacillary forms. Also, the nasal biopsies of two patients were the only exam to show positivity. The bacillary index of the nasal biopsy was strongly correlated to skin biopsy and slit-skin smear. Additionally, the agreement among the exams was good, revealing the reliability of the nasal biopsy in leprosy diagnosis. Conclusion The present study showed a rate of 48% of positivity in nasal biopsy of untreated patients, correlating well with skin biopsy and skin smear. Thus, the method in leprosy diagnosis and clinical form classification has shown great reliability. |
| Databáze: | OpenAIRE |
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