18F-FET and 18F-choline PET-CT in patients with MRI-suspected low-grade gliomas: a pilot study
| Autor: | Ana Mišir Krpan, Marijan Žuvić, Dražen Huić, Maja Baučić, Goran Mrak, Jakob Nemir, Anja Tea Golubić, Marina Hodolič |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Glioma* / diagnostic imaging
Pilot Projects Choline Positron Emission Tomography Computed Tomography medicine Humans Brain Neoplasms* / diagnostic imaging PET-CT medicine.diagnostic_test Receiver operating characteristic business.industry Brain Neoplasms Area under the curve Magnetic resonance imaging General Medicine Odds ratio Glioma Magnetic Resonance Imaging Confidence interval Choline / analogs & derivatives Positron emission tomography Positron-Emission Tomography Tyrosine F-18-choline glioma F-18-FET Radiopharmaceuticals Nuclear medicine business Kappa Research Article |
| Zdroj: | Croatian Medical Journal Volume 62 Issue 4 |
| ISSN: | 1332-8166 0353-9504 |
| Popis: | Aim: To investigate the diagnostic accuracy of O-(2-[18F]-fluoroethyl)-L-tyrosine (18F-FET) and fluoromethyl-(18F)-dimethyl-2-hydroxyethyl-ammonium chloride (18F-FCH) computed tomography (CT) in patients with primary low-grade gliomas (LGG). ----- Methods: The study enrolled patients with magnetic resonance imaging (MRI)-suspected LGG. Patients underwent both 18F-FET and 18F-FCH positron emission tomography (PET)-CT. Brain PET-CT was performed according to standard protocol - 20 minutes after intravenous injection of 185 MBq of 18F-FET and 185 MBq of 18F-FCH PET. Surgery and pathohistological diagnosis were performed in the next two weeks. ----- Results: We observed significantly better concordance between tumor histology and 18F-FET PET (weighted Kappa 0.74) compared with both 18F-FCH (weighted Kappa 0.15) and MRI (weighted Kappa 0.00). Tumor histology was significantly associated with 18F-FET (odds ratio 12.87; 95% confidence interval [CI], 0.49-333.70; P=0.013, logistic regression analysis). Receiver operating characteristic curve analysis comparing 18F-FCH (area under the curve [AUC] 0.625, 95% CI 0.298-0.884) and 18F-FET (AUC 0.833, 95% CI 0.499-0.982) showed better diagnostic properties of 18F-FET (AUC difference 0.208, 95% CI -0.145 to 0.562, P=0.248). ----- Conclusion: Performing PET-CT in patients with newly diagnosed LGG should be preceded by a selection of an appropriate radiopharmaceutical. 18F-FET seems to be more accurate than 18F-FCH in the LGG diagnosis. |
| Databáze: | OpenAIRE |
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