Heat-inactivated Mycobacterium bovis protects zebrafish against mycobacteriosis
| Autor: | Lourdes Mateos-Hernández, José de la Fuente, Vladimir López, Joaquín Vicente, María Ángeles Risalde, Marinela Contreras, Christian Gortázar |
|---|---|
| Přispěvatelé: | Universidad Autónoma de Sinaloa, Ministerio de Economía y Competitividad (España), Agencia Estatal de Investigación (España), Instituto de Investigación en Recursos Cinegéticos (IREC), US ANIHWA, Institut National de la Recherche Agronomique (INRA), Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University [Stillwater], Sabiotec, Ministerio de Economia y Competitividad [AGL2014-56305] |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Hot Temperature Tuberculosis 040301 veterinary sciences Veterinary (miscellaneous) [SDV]Life Sciences [q-bio] Aquatic Science Microbiology fish mycobacteriosis 0403 veterinary science complement component C3 Fish Diseases 03 medical and health sciences fish innate immunity vaccine medicine Animals Zebrafish Mycobacterium marinum Mycobacterium bovis Microbial Viability Innate immune system biology Animal health Tb control Vaccination 04 agricultural and veterinary sciences biology.organism_classification medicine.disease zebrafish Immunity Innate Disease Models Animal Oral immunization 030104 developmental biology Vaccines Inactivated tuberculosis |
| Zdroj: | Journal of Fish Diseases Journal of Fish Diseases, Wiley, 2018, 41 (10), pp.1515-1528. ⟨10.1111/jfd.12847⟩ Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 0140-7775 1365-2761 |
| DOI: | 10.1111/jfd.12847⟩ |
| Popis: | Control of mycobacterial infection constitutes a priority for human and animal health worldwide. However, effective vaccines are needed for the control of human and animal tuberculosis (TB). Adult zebrafish have become a useful model for studying the pathophysiology of mycobacterial infection and for the development of novel interventions for TB control and prevention. Recently, parenteral and oral immunization with the heat-inactivated Mycobacterium bovis vaccine (M. bovis IV) protected wild boar against TB. The objectives of this study were to provide additional support for the role of M. bovis IV in TB control using the zebrafish model and to conduct the first trial with this vaccine for the control of fish mycobacteriosis. The results showed that M. bovis IV protected zebrafish against mycobacteriosis caused by low and high infection doses of Mycobacterium marinum and provided evidence suggesting that the protective mechanism elicited by M. bovis IV in zebrafish as in other species is based on the activation of the innate immune response through the C3 pathway, with a role for the regulatory protein Akr2 in this process. These results encourage the use of M. bovis IV for TB control in different species. L was supported by a grant from Universidad Autónoma de Sinaloa, Mexico. This research was supported by project Art. 83 with Sabiotec, Spain. This study is also a contribution to grant AGL2014-56305 from Ministerio de Economía y Competitividad, Spain. |
| Databáze: | OpenAIRE |
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