| Autor: |
Ting Li, Ying Zhang, Jie Zhu, Fangrui Zhang, An'an Xu, Tian Zhou, Yaoqi Li, Ming Liu, Hengte Ke, Tao Yang, Yong'an Tang, Jing Tao, Liyan Miao, Yibin Deng, Huabing Chen |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Advanced materials (Deerfield Beach, Fla.). |
| ISSN: |
1521-4095 |
| Popis: |
Artificial enzymes have demonstrated therapeutic benefit against diverse malignant tumors, yet their antitumor potencies are still severely compromised by non-selective catalysis, low atomic utilization efficiency, and undesired off-target toxicity. Herein, we report that the peroxidase-like biomineralized copper (II) carbonate hydroxide nanocrystals inside single albumin nanocages (CuCH-NCs) act as a pH-activatable proenzyme to achieve tumor-selective and synergistic chemodynamic/chemo-immunotherapy against aggressive triple-negative breast cancers (TNBCs). These CuCH-NCs show pH-sensitive Cu |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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