Serum Insulin-Like Growth Factor-I Levels and Prostatic Intraepithelial Neoplasia: A Clue to the Relationship Between IGF-I Physiology and Prostate Cancer Risk
| Autor: | Marjan Emami, Michael A.S. Jewett, Andrew Evans, Robert K. Nam, Steven A. Narod, John Trachtenberg, Ants Toi, Michael Pollak |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
Canada Prostate biopsy Epidemiology Physiology Reference range Prostate cancer Risk Factors Prostate Odds Ratio medicine Humans Insulin-Like Growth Factor I Risk factor Aged Prostatic Intraepithelial Neoplasia Intraepithelial neoplasia medicine.diagnostic_test business.industry Case-control study Prostatic Neoplasms Rectal examination Middle Aged Prostate-Specific Antigen medicine.disease Insulin-Like Growth Factor Binding Protein 3 medicine.anatomical_structure Oncology Case-Control Studies business |
| Zdroj: | Cancer Epidemiology, Biomarkers & Prevention. 14:1270-1273 |
| ISSN: | 1538-7755 1055-9965 |
| DOI: | 10.1158/1055-9965.epi-04-0430 |
| Popis: | Serum insulin-like growth factor-I (IGF-I) levels at the higher end of the reference range have been associated with increased risk for the future development of prostate cancer. We determined whether high serum IGF-I levels are associated with precancerous lesions of the prostate. We conducted a case-control study to determine whether high serum IGF-I levels were associated with the presence of high-grade prostatic intraepithelial neoplasia (HGPIN) among patients who presented for prostate biopsy because of an abnormal serum prostate-specific antigen level or digital rectal exam. We measured serum IGF-I and insulin-like growth factor binding protein-3 (IGFBP-3) prior to prostate biopsy and compared them between 103 men with HGPIN (cases) and 205 men with normal prostate histology (controls). The mean IGF-I level in patients with HGPIN (130.2 ng/mL) was significantly higher compared with controls (118.8 ng/mL, P = 0.01). The mean IGFBP-3 level in patients with HGPIN (2,393.9 ng/mL) was also higher compared with controls (2,276.0 ng/mL, P = 0.06). After adjusting for age, prostate-specific antigen, digital rectal examination, and ethnic background, the odds ratio for a HGPIN diagnosis among men in the highest relative to the lowest quartile of serum IGF-I level was 1.94 (95% confidence interval, 1.0-3.7; P = 0.04). The potential association between a high serum IGF-I level and the presence of HGPIN may represent an important clue to understanding the basis for the relationship between IGF-I physiology and prostate cancer risk. Larger studies will be required to confirm this relationship. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|