Mapping Plasmodium falciparum mortality in Africa between 1990 and 2015
| Autor: | Stephen S Lim, Donal Bisanzio, Jennifer Rozier, Haidong Wang, Samir Bhatt, Peter W. Gething, Puja C Rao, Christopher J L Murray, Matthew M Coates, Mohsen Naghavi, Daniel C Casey, Simon I. Hay, Katya Anne Shackelford, Ryan M Barber, Ursula Dalrymple, Grant Nguyen, Chantal Huynh, David L. Smith, Rachel Kulikoff, Katherine E. Battle, Maya S Fraser, Daniel J. Weiss, Ewan Cameron, Michael Kutz |
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| Přispěvatelé: | Medical Research Council (MRC) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
IMPACT
Geographic Mapping MALARIA CONTROL DISEASE Parasite Load law.invention 0302 clinical medicine law Case fatality rate Prevalence Medicine 030212 general & internal medicine Young adult Malaria Falciparum Child education.field_of_study biology Incidence (epidemiology) General Medicine 11 Medical And Health Sciences Transmission (mechanics) Child Preschool BURDEN Life Sciences & Biomedicine Adult medicine.medical_specialty Adolescent TRANSMISSION 030231 tropical medicine Population Plasmodium falciparum Article 03 medical and health sciences Drug treatment Antimalarials Young Adult Medicine General & Internal AGE General & Internal Medicine parasitic diseases SYSTEMATIC ANALYSIS Humans Insecticide-Treated Bednets Mortality education Africa South of the Sahara Science & Technology Models Statistical business.industry Infant Newborn Infant medicine.disease biology.organism_classification Surgery Communicable Disease Control business Malaria RESISTANCE Demography |
| Popis: | Background Malaria control has not been routinely informed by the assessment of subnational variation in malaria deaths. We combined data from the Malaria Atlas Project and the Global Burden of Disease Study to estimate malaria mortality across sub-Saharan Africa on a grid of 5 km(2) from 1990 through 2015. Methods We estimated malaria mortality using a spatiotemporal modeling framework of geolocated data (i.e., with known latitude and longitude) on the clinical incidence of malaria, coverage of antimalarial drug treatment, case fatality rate, and population distribution according to age. Results Across sub-Saharan Africa during the past 15 years, we estimated that there was an overall decrease of 57% (95% uncertainty interval, 46 to 65) in the rate of malaria deaths, from 12.5 (95% uncertainty interval, 8.3 to 17.0) per 10,000 population in 2000 to 5.4 (95% uncertainty interval, 3.4 to 7.9) in 2015. This led to an overall decrease of 37% (95% uncertainty interval, 36 to 39) in the number of malaria deaths annually, from 1,007,000 (95% uncertainty interval, 666,000 to 1,376,000) to 631,000 (95% uncertainty interval, 394,000 to 914,000). The share of malaria deaths among children younger than 5 years of age ranged from more than 80% at a rate of death of more than 25 per 10,000 to less than 40% at rates below 1 per 10,000. Areas with high malaria mortality (>10 per 10,000) and low coverage ( |
| Databáze: | OpenAIRE |
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