Advances and Challenges on Cancer Cells Reprogramming Using Induced Pluripotent Stem Cells Technologies
| Autor: | Irina Kerkis, Diana Aparecida Dias Câmara, Allan Saj Porcacchia, Lisley I. Mambelli |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
education.field_of_study Cancer cells Yamanaka`s factors Cellular differentiation Population Cancer Reprogramming Review Biology medicine.disease Embryonic stem cell Cell biology 03 medical and health sciences 030104 developmental biology Oncology Cancer cell medicine Stem cell Induced pluripotent stem cell education Induced pluripotent stem cells |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 |
| DOI: | 10.7150/jca.16629 |
| Popis: | Cancer cells transformation into a normal state or into a cancer cell population which is less tumorigenic than the initial one is a challenge that has been discussed during last decades and it is still far to be solved. Due to the highly heterogeneous nature of cancer cells, such transformation involves many genetic and epigenetic factors which are specific for each type of tumor. Different methods of cancer cells reprogramming have been established and can represent a possibility to obtain less tumorigenic or even normal cells. These methods are quite complex, thus a simple and efficient method of reprogramming is still required. As soon as induced pluripotent stem cells (iPSC) technology, which allowed to reprogram terminally differentiated cells into embryonic stem cells (ESC)-like, was developed, the method strongly attracted the attention of researches, opening new perspectives for stem cell (SC) personalized therapies and offering a powerful in vitro model for drug screening. This technology is also used to reprogram cancer cells, thus providing a modern platform to study cancer-related genes and the interaction between these genes and the cell environment before and after reprogramming, in order to elucidate the mechanisms of cancer initiation and progression. The present review summarizes recent advances on cancer cells reprogramming using iPSC technology and shows the progress achieved in such field. |
| Databáze: | OpenAIRE |
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