Is Regional Lymph Node Metastasis of Head and Neck Paraganglioma a Sign of Aggressive Clinical Behavior: A Clinical/Pathologic Review
| Autor: | Ritu Ghai, Paolo Gattuso, Sara Javidiparsijani, Diana Murro Lin, Arlen Brickman, Pincas Bitterman, Vijaya Reddi, Prih Rohra, Samer Al-Khudari |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Paraganglioma Young Adult Regional lymph node metastasis medicine Humans Neoplasm Head and neck Aged Retrospective Studies Sentinel Lymph Node Biopsy business.industry Head and neck tumors Clinical course Middle Aged medicine.disease Otorhinolaryngology Head and Neck Neoplasms Lymphatic Metastasis Female Lymph Nodes Radiology business Sign (mathematics) |
| Zdroj: | Ear, Nose & Throat Journal. 100:447-453 |
| ISSN: | 1942-7522 0145-5613 |
| DOI: | 10.1177/0145561319863373 |
| Popis: | Background: Head and neck paraganglioma is a rare neoplasm of the paraganglia. It accounts for Design: From 1993 to 2016, primary head and neck paragangliomas are identified. The patient clinical and histopathologic materials were reviewed. Results: Sixty-five specimens from 62 patients (3 patients with more than 1 specimens) with head and neck paragangliomas were recorded (49 female and 13 males) with mean age of 54 (24-78 years). The locations of the tumors were as follows: carotid body: 30, glomus tympanicum: 11, glomus jugulare: 14, parapharyngeal space: 3, and 1 case each of larynx, skull base, paraglottic area, infratemporal fossa, mastoid, cerebellopontine (CP) angle, and pyriform sinus. On histopathology, we found 5 cases of sclerosing variant. Thirty-two (52%) of the 62 patients had regional lymph node biopsy. Four (12%) of the 32 show metastatic paraganglioma (3 females and 1 male with mean age = 35). Two of the 5 cases of sclerosing variant had positive lymph nodes. No evidence of local recurrence or distant metastasis in the patients with positive lymph nodes with a 6 to 11 years follow-up. One of the 28 patients with negative lymph nodes developed metastatic disease to lumbar spine in 5 years. Conclusion: Metastatic paraganglioma to regional lymph nodes may have indolent clinical behavior, with disease-free survival of up to 11 years. The incidence of metastatic disease in lymph nodes was 4 (12%) of 32. Forty percent (2/5) of the cases with sclerosing variant of paraganglioma had lymph node metastases indicating that this tumor may have a more aggressive histological behavior. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|