Coinfection by HTLV-I/II is associated with an increased risk of strongyloidiasis and delay in starting antiretroviral therapy for AIDS patients
| Autor: | J. Sampaio, William J. Harrington, S. Adriano, Eduardo Martins Netto, Celia Pedroso, Carlos Brites, F. Goyanna, L.G. França |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Lymphocyte Encephalopathy lcsh:QR1-502 Gastroenterology lcsh:Microbiology lcsh:Infectious and parasitic diseases Acquired immunodeficiency syndrome (AIDS) Internal medicine medicine lcsh:RC109-216 Risk factor Immunodeficiency HTLV-I/II Medicine(all) CD4/CD8 business.industry virus diseases HIV medicine.disease medicine.anatomical_structure Strongyloidiasis Infectious Diseases coinfection Strongyloidiasis Immunology Coinfection business CD8 |
| Zdroj: | Brazilian Journal of Infectious Diseases, Volume: 15, Issue: 1, Pages: 11-6, Published: FEB 2011 Brazilian Journal of Infectious Diseases, Vol 15, Iss 1, Pp 6-11 ResearcherID Brazilian Journal of Infectious Diseases, Vol 15, Iss 1, Pp 6-11 (2011) Brazilian Journal of Infectious Diseases v.15 n.1 2011 Brazilian Journal of Infectious Diseases Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
| Popis: | Objective: To compare the clinical characteristics and outcomes of HIV-1-HTLV-1 coinfected patients, in Bahia, Brazil. Methods: Retrospective, comparative study. Results: Among a total of 123 consecutive HIV infected patients, 20 men (20.6%) and 6 women (23.1%) had detectable antibodies against HTLV-I/II. The major risk factor associated with coinfection by HTLV was intravenous drug use (57.7% of coinfected patient versus 9.2% of HTLV seronegative patients, p < 0.0001). Coinfected patients had higher absolute lymphocyte counts (1,921 + 762 versus 1,587 + 951, p = 0.03). Both groups of patients had similar means of CD4+ and CD8+ cell counts. However, among patients with AIDS CD4+ cell counts were significantly higher among those coinfected with HTLV-I/II (292 ± 92 cells/mm3, versus 140 ± 177cells/mm3, p = 0.36). The frequency and type of opportunistic infections were similar for both groups, but strongyloidiasis and encephalopathy were more frequently diagnosed in coinfected patients (p < 0.05). On the other hand, patients coinfected with HTLV-I/II received significantly less antiretroviral therapy than singly infected by HIV-1 Conclusion: Coinfection by HTLV-I/II is associated with an increased risk of strongyloidiasis for HIV patients. Higher CD4 count may lead to underestimation of immunodeficiency, and delay to initiate antiretroviral therapy. Keywords: HIV, HTLV-I/II, coinfection Strongyloidiasis, CD4/CD8 |
| Databáze: | OpenAIRE |
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