A new malyngamide from the marine cyanobacterium Moorea producens
| Autor: | Hajime Uchida, Raymie Othman, Ryuichi Watanabe, Weina Jiang, Bryan Sakamoto, Wei Zhou, Hiroshi Nagai, Toshiyuki Suzuki |
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| Rok vydání: | 2017 |
| Předmět: |
Cyanobacteria
Aquatic Organisms Magnetic Resonance Spectroscopy Stereochemistry Plant Science 01 natural sciences Biochemistry Analytical Chemistry Palaemon paucidens Lipopeptides Mice Structure-Activity Relationship Cell Line Tumor Botany L1210 cell Moiety Animals Pyrroles Cytotoxicity Leukemia L1210 Moorea producens chemistry.chemical_classification biology Molecular Structure 010405 organic chemistry Organic Chemistry Fatty acid biology.organism_classification Amides 0104 chemical sciences Shrimp 010404 medicinal & biomolecular chemistry chemistry Palaemonidae |
| Zdroj: | Natural product research. 32(1) |
| ISSN: | 1478-6427 |
| Popis: | A new malyngamide (1) was isolated along with seven known compounds (2–8) from the marine cyanobacterium Moorea producens collected in Hawaii. Compound 1 represented the first reported malyngamide with a hydroxy moiety at C-7 of the characteristic fatty acid portion of the compound. Compound 1 showed cytotoxicity against L1210 cell line at an IC50 value of 2.9 mM and lethal toxicity against the shrimp Palaemon paucidens at a LD100 value of 33.3 mg/kg. The bioactivity of compound 1 was approximately 10–100 times weaker than those of isomalyngamides A and B (3, 4). These results indicated that the methoxy group at C-7 of the fatty acid section confers a degree of bioactivity in malyngamides. |
| Databáze: | OpenAIRE |
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