N-(6,7-Dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-d-aspartate receptor antagonists for the treatment of pain

Autor:	Xinmin Gan, Laurence Philippe, Brian Sanchez, Karen M. Yates, Ziqiang Wang, Arun K. Agrawal, Pil H. Lee, Cho Ming Loi, Zhen Lou, Haile Tecle, Jo Ann Dumin, Sheila Guppy, Frank Riley, Joan K. Brieland, Christopher James Deur, Sally Przybranowski, Brian Samas, Amy Mae Bunker, Mark Morris, Michael William Wilson, John Richard Booth, Joseph A. Cornicelli, Susan E. Bove, Cleo J. C. Connolly, Gregg Kamilar, Kenneth S. Kilgore, Barry C. Finzel, Heidi Baum, Kathryn A. Welch
Rok vydání:	2007
Předmět:	Models Molecular medicine.medical_specialty Clinical Biochemistry Analgesic Pain Pharmaceutical Science Quinoxalinedione Blood–brain barrier Receptors N-Methyl-D-Aspartate Biochemistry Chemical synthesis Structure-Activity Relationship chemistry.chemical_compound Internal medicine Drug Discovery medicine Animals Molecular Biology Analgesics Sulfonamides Atropisomer Binding Sites Molecular Structure Organic Chemistry Glutamate receptor Antagonist Rats medicine.anatomical_structure Endocrinology nervous system chemistry Area Under Curve Molecular Medicine NMDA receptor Protein Binding
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 17:4599-4603
ISSN:	0960-894X
Popis:	It has been hypothesized that peripherally restricted NMDA receptor antagonists may be effective analgesics for osteoarthritis pain. A class of novel quinoxalinedione atropisomers, first discovered for an NMDA receptor antagonist program for the treatment of stroke, was evaluated and further optimized with the goal of finding peripherally restricted NMDA receptor antagonists.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcf8a8aa89569f777c79f4224db99ed https://doi.org/10.1016/j.bmcl.2007.05.083 Zobrazit plný text záznamu Full Text from ScienceDirect