Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration

Autor:	Vobalaboina Venkateswarlu, Kopparam Manjunath
Rok vydání:	2005
Předmět:	Male Duodenum medicine.drug_class Chemistry Pharmaceutical Biological Availability Pharmaceutical Science Atypical antipsychotic Pharmacology Mice First pass effect Suspensions Pharmacokinetics Solid lipid nanoparticle Electrochemistry medicine Animals Distribution (pharmacology) Tissue Distribution Particle Size Rats Wistar Clozapine Intubation Gastrointestinal Chemistry Nanostructures Rats Bioavailability Area Under Curve Injections Intravenous Drug metabolism Antipsychotic Agents medicine.drug
Zdroj:	Journal of Controlled Release. 107:215-228
ISSN:	0168-3659
DOI:	10.1016/j.jconrel.2005.06.006
Popis:	Clozapine, a lipophilic effective atypical antipsychotic drug, has very poor oral bioavailability (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcd46761892346388f920536e100746 https://doi.org/10.1016/j.jconrel.2005.06.006 Zobrazit plný text záznamu Full Text from ScienceDirect