Novel carboxylated ferrocene polymer nanocapsule with high reactive oxygen species sensitivity and on-demand drug release for effective cancer therapy
| Autor: | Daekyung Sung, Won Il Choi, Yoonhee Na, Jiseob Woo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Metallocenes
Polymers 02 engineering and technology Methacrylate 01 natural sciences Nanocapsules chemistry.chemical_compound Colloid and Surface Chemistry Neoplasms 0103 physical sciences Amphiphile Physical and Theoretical Chemistry chemistry.chemical_classification Reactive oxygen species 010304 chemical physics Chemistry Surfaces and Interfaces General Medicine 021001 nanoscience & nanotechnology Combinatorial chemistry Drug Resistance Multiple Multiple drug resistance Drug Liberation Paclitaxel Ferrocene Doxorubicin Drug Resistance Neoplasm 0210 nano-technology Reactive Oxygen Species Intracellular Biotechnology |
| Zdroj: | Colloids and surfaces. B, Biointerfaces. 200 |
| ISSN: | 1873-4367 |
| Popis: | Multidrug resistance (MDR) is a major clinical issue leading to substantial reductions in the intracellular levels of anticancer drugs. To overcome MDR, stimulus-responsive polymeric nanotherapeutics that facilitate drug release and cellular uptake at target sites have emerged as promising tools for safe and effective cancer treatment. Among these nanotherapeutics, reactive oxygen species (ROS)-responsive nanocapsules are ideal carriers, as abnormally increased ROS levels can drive controlled drug release at target sites. In this study, we developed novel, high ROS-responsive carboxylated ferrocene nanocapsules (CFNCs) using solvents of different polarities for effective multidrug-resistant cancer therapy. The CFNCs were prepared via the self-assembly of an amphiphilic carboxylated ferrocene polymer composed of a hydrophilic COOH segment and a hydrophobic ferrocenylmethyl methacrylate segment possessing a ROS-responsive group. The size and ROS sensitivity of self-assembled CFNCs could be controlled by using solvents of different polarities during the simple nanoprecipitation process. The CFNCs showed a high loading content (approximately 30 wt%) and on-demand release of paclitaxel under both normal and tumor-mimicking conditions, and exhibited synergistic anticancer effects in multidrug-resistant colorectal cancer cells (HCT-15). Our findings suggest that CFNCs can be applied as carriers for effective cancer therapy. |
| Databáze: | OpenAIRE |
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