Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging
| Autor: | Gene L. Bowman, Diane B. Howieson, Jeffrey Kaye, Hiroko H. Dodge, Lisa C. Silbert, Balz Frei, Joseph F. Quinn, Jackilen Shannon, Maret G. Traber |
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| Přispěvatelé: | Laboratoire de Psychologie des Pays de la Loire (LPPL), Université d'Angers (UA)-Université de Nantes - UFR Lettres et Langages (UFRLL), Université de Nantes (UN)-Université de Nantes (UN) |
| Rok vydání: | 2011 |
| Předmět: |
Male
Aging Pathology Neurology Apolipoprotein E3 Physiology Neuropsychological Tests Polymerase Chain Reaction [SHS]Humanities and Social Sciences Cohort Studies Cognition 0302 clinical medicine Risk Factors Image Processing Computer-Assisted 030212 general & internal medicine ComputingMilieux_MISCELLANEOUS Depression (differential diagnoses) Aged 80 and over 0303 health sciences education.field_of_study Cognitive Symptoms Brain Vitamins Articles Middle Aged Magnetic Resonance Imaging Cohort Brain size Regression Analysis Biomarker (medicine) Female Cohort study medicine.medical_specialty Community dwellers Psychometrics Population Automated segmentation Nutritional Status Biology 03 medical and health sciences Fatty Acids Omega-3 medicine Humans education Demography 030304 developmental biology business.industry ad Diet Dementia Neurology (clinical) business Neuroscience Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Neurology Neurology, American Academy of Neurology, 2012, 78 (16), pp.1281-1282. ⟨10.1212/01.wnl.0000414241.41860.13⟩ |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/wnl.0b013e3182436598 |
| Popis: | Objective: To examine the cross-sectional relationship between nutrient status and psychometric and imaging indices of brain health in dementia-free elders. Methods: Thirty plasma biomarkers of diet were assayed in the Oregon Brain Aging Study cohort (n = 104). Principal component analysis constructed nutrient biomarker patterns (NBPs) and regression models assessed the relationship of these with cognitive and MRI outcomes. Results: Mean age was 87 ± 10 years and 62% of subjects were female. Two NBPs associated with more favorable cognitive and MRI measures: one high in plasma vitamins B (B1, B2, B6, folate, and B12), C, D, and E, and another high in plasma marine ω-3 fatty acids. A third pattern characterized by high trans fat was associated with less favorable cognitive function and less total cerebral brain volume. Depression attenuated the relationship between the marine ω-3 pattern and white matter hyperintensity volume. Conclusion: Distinct nutrient biomarker patterns detected in plasma are interpretable and account for a significant degree of variance in both cognitive function and brain volume. Objective and multivariate approaches to the study of nutrition in brain health warrant further study. These findings should be confirmed in a separate population. Neurology ® 2012;78:241–249 |
| Databáze: | OpenAIRE |
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