Melatonin restores zinc levels, activates the Keap1/Nrf2 pathway, and modulates endoplasmic reticular stress and HSP in rats with chronic hepatotoxicity

Autor: Silvia Bona, Sabrina Alves Fernandes, Andrea C Janz Moreira, Graziella Rodrigues, Elizângela G Schemitt, Fabio Cangeri Di Naso, Cláudio A Marroni, Norma P Marroni
Rok vydání: 2022
Zdroj: World Journal of Gastrointestinal Pharmacology and Therapeutics. 13:11-22
ISSN: 2150-5349
Popis: Melatonin (MLT) is a potent antioxidant molecule that is shown to have a beneficial effect in various pathological situations, due to its action against free radicals.To evaluate the effect of MLT on carbon tetrachloride (CClTwenty male Wistar rats (230-250 g) were divided into four groups: Control rats, rats treated with MLT alone, rats treated with CClMLT was able to reduce the release of liver enzymes in the bloodstream and to decrease oxidative stress in CClMLT has a hepatoprotective effect in an experimental model of CCl
Databáze: OpenAIRE