Analysis of the codon usage of the ORF2 gene of feline calicivirus
| Autor: | Bohao Wu, Fanshu Du, Wanting He, Gongjian Wu, Minghui Zang, Zhenlei Zhou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Genes Viral viruses Mutation pressure Natural selection 030106 microbiology Neutrality analysis Biology Cat Diseases Microbiology Article 03 medical and health sciences Genetics Animals Feline calicivirus Codon Molecular Biology Pathogen Gene Ecology Evolution Behavior and Systematics Caliciviridae Infections biology.organism_classification Virology Orf2 gene 030104 developmental biology Infectious Diseases Codon usage bias Cats Codon usage Open reading frame 2 (ORF2) Calicivirus Feline |
| Zdroj: | Infection, Genetics and Evolution |
| ISSN: | 1567-7257 1567-1348 |
| Popis: | Feline calicivirus (FCV) is a highly prevalent pathogen of the domestic cat that causes acute infections of the oral and upper respiratory tract. The E region of the ORF2 protein is responsible for the induction of virus-neutralizing antibodies, thus it is important to understand the codon usage of this gene. Here, analysed 90 coding sequences of ORF2 and show that it undergoes a low codon usage bias. In addition, although mutational bias is one of the factors shaping the codon usage bias of this gene, natural selection plays a more significant role. Our results reveal part of the mechanisms driving FCV evolution, which will lay foundation for the further research of FCV. Highlights • The codon usage of the ORF2 gene of FCV was first analysed in this study. • The ORF2 gene of FCV shows a low codon usage bias. |
| Databáze: | OpenAIRE |
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