Metal-organic frameworks-derived bimetallic nanozyme platform enhances cytotoxic effect of photodynamic therapy in hypoxic cancer cells
| Autor: | Yang Li, Zhenqi Jiang, Yulin Deng, Jieling Qin, Zeyu Song, Xiao Han, Ying Zhou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Materials science
medicine.medical_treatment chemistry.chemical_element Photodynamic therapy 02 engineering and technology 010402 general chemistry 01 natural sciences Oxygen medicine Cytotoxic T cell General Materials Science Nanozymes Bimetallic strip Materials of engineering and construction. Mechanics of materials chemistry.chemical_classification Reactive oxygen species Mechanical Engineering Hypoxia (medical) Metal-organic frameworks Hypoxic environments 021001 nanoscience & nanotechnology eye diseases 0104 chemical sciences chemistry Mechanics of Materials Cancer cell Cancer research TA401-492 Metal-organic framework medicine.symptom 0210 nano-technology |
| Zdroj: | Materials & Design, Vol 204, Iss, Pp 109646-(2021) |
| ISSN: | 0264-1275 |
| Popis: | Photodynamic therapy (PDT) is increasingly accepted as a cancer treatment because it can target the tumor precisely and treat it noninvasively. The therapeutic effect of PDT is generally affected by three parameters: the light, the photosensitizers (PSs), and the local oxygen, where the performance of the PSs with light is greatly affected by the availability of local oxygen. However, hypoxia is one of the typical characteristics of the microenvironment in solid tumors, which renders the efficacy of PDT in cancer treatment. Here, we introduced a novel nanozyme platform, which composed of metal-organic frameworks (MOF) derived materials and could directly load the PSs. The nanozyme could generate oxygen by catalyzing H2O2, which enhanced the production of reactive oxygen species (ROS) and resulted in an improved cytotoxic effect of the PSs. We showed that, especially under the hypoxic environment, this nanozyme could alleviate the hypoxic situation by generating oxygen in the H2O2 solution and further improved the therapeutic effect of PDT consequently. In conclusion, this nanozyme platform allows the loading of PSs with ease and can catalyze H2O2 to generate oxygen to enhance the effect of PDT for cancer treatment in both normoxic and hypoxic environments. |
| Databáze: | OpenAIRE |
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