Sow Vaccination with a Protein Fragment against Virulent Glaesserella (Haemophilus) parasuis Modulates Immunity Traits in Their Offspring
| Autor: | Marina Sibila, I. Galindo-Cardiel, Jorge Martínez-Martínez, Mar Costa-Hurtado, Ayub Darji, Sergi López-Serrano, Yasser S. Mahmmod, Carlos Neila-Ibáñez, Fernando Rodriguez, Virginia Aragon |
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| Přispěvatelé: | Producció Animal, Sanitat Animal |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
040301 veterinary sciences Offspring Swine medicine.medical_treatment animal diseases Immunology Virulence Passive immunity Article Microbiology 0403 veterinary science 03 medical and health sciences Glaesserella parasuis fluids and secretions Immunity vaccine Drug Discovery Haemophilus medicine Pharmacology (medical) Disease bacteria Pharmacology disease biology Bacteria swine 04 agricultural and veterinary sciences biology.organism_classification Vaccination 030104 developmental biology Infectious Diseases biology.protein Colostrum Medicine Antibody Vaccine |
| Zdroj: | Vaccines, Vol 9, Iss 534, p 534 (2021) Vaccines Volume 9 Issue 5 Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona IRTA Pubpro. Open Digital Archive Institut de Recerca i Tecnologia Agroalimentàries (IRTA) |
| Popis: | Glaesserella (Haemophilus) parasuis, an early colonizer of the nasal cavity in piglets, is a highly heterogeneous species, comprising both commensal and virulent strains. Virulent G. parasuis strains can cause fibrinous polyserositis called Glässer's disease. Colostrum is a source of passive immunity for young piglets. When vaccinating sows, protective antibodies are transferred to their offspring through the colostrum. Here, sow vaccination was performed with a protein fragment, F4, from the outer membrane trimeric autotransporters VtaAs exclusively found in virulent G. parasuis. Piglets were allowed to suckle for 3 weeks, following which a challenge with two virulent strains of G. parasuis was performed. A group of nonvaccinated sows and their piglets were included as a control. Antibodies against F4 were confirmed using ELISA in the vaccinated sows and their offspring before the G. parasuis challenge. Compared to the control group, F4-vaccination also resulted in an increased level of serum TGF-β both in vaccinated sows and in their offspring at early time points of life. After the challenge, a lower body temperature and a higher weight were observed in the group of piglets from vaccinated sows. One piglet from the non-vaccinated group succumbed to the infection, but no other significant differences in clinical signs were noticed. At necropsy, performed 2 weeks after the virulent challenge, the level of surfactant protein D (SP-D) in bronchoalveolar lavage was higher in the piglets from vaccinated sows. Vaccination did not inhibit the nasal colonization of the piglets by the challenge strains. info:eu-repo/semantics/publishedVersion |
| Databáze: | OpenAIRE |
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