Olive oil and its main phenolic micronutrient (oleuropein) prevent inflammation-induced bone loss in the ovariectomised rat

Autor: Patrice Lebecque, Christiane Obled, Marie-Jeanne Davicco, A. Mazur, Véronique Coxam, Apostolos Agalias, A. Quintin, C. Puel, J. Mathey, Alexios-Leandros Skaltsounis
Přispěvatelé: Unité de recherche Maladies Métaboliques et Micronutriments (U3M), Institut National de la Recherche Agronomique (INRA), Unité de nutrition et métabolisme protéique, ProdInra, Migration
Jazyk: angličtina
Rok vydání: 2004
Předmět:
Deoxypyridinoline
Bone disease
Medicine (miscellaneous)
chemistry.chemical_compound
0302 clinical medicine
Anti-Infective Agents
Bone Density
Osteogenesis
Iridoids
ComputingMilieux_MISCELLANEOUS
2. Zero hunger
0303 health sciences
Nutrition and Dietetics
biology
Chemistry
Uterine horns
Organ Size
Orosomucoid
Osteocalcin
Female
CONTROLE DE MALADIES
medicine.medical_specialty
food.ingredient
Ovariectomy
Iridoid Glucosides
OLEUROPINE
030209 endocrinology & metabolism
Bone resorption
03 medical and health sciences
food
Dietary Fats
Unsaturated
Oleuropein
Internal medicine
medicine
Animals
Plant Oils
Bone Resorption
Rats
Wistar
Olive Oil
Pyrans
030304 developmental biology
Inflammation
Uterus
medicine.disease
Rats
Osteopenia
Bone Diseases
Metabolic
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition
Endocrinology
biology.protein
Peanut oil
RAT
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Biomarkers
Zdroj: British Journal of Nutrition
British Journal of Nutrition, Cambridge University Press (CUP), 2004, 92 (1), pp.119-127
ISSN: 0007-1145
1475-2662
Popis: The present study was designed to evaluate the effect of olive oil and its main polyphenol (oleuropein) in ovariectomised rats with or without inflammation. Rats (6 months old) were ovariectomised or sham-operated as control. Ovariectomised rats were separated into three groups receiving different diets for 3 months: a control diet with 25 g peanut oil and 25 g rapeseed oil/kg (OVX), the control diet with 50 g olive oil/kg or the control diet with 0·15 g oleuropein/kg. The sham-operated group was given the same control diet as OVX. Inflammation was induced 3 weeks before the end of the experiment by subcutaneous injections of talc (magnesium silicate) in one-half of each group. The sucess of ovariectomy was verified at necropsy by the atrophy of uterine horns. Inflammation, oleuropein or olive oil intakes did not have any uterotrophic activity, as they had had no effect on uterus weight. The plasma concentration of α-1-acid glycoprotein (an indicator of inflammation) was increased in OVX rats with inflammation. With regard to bone variables, osteopenia in OVX was exacerbated by inflammation, as shown by a decrease in metaphyseal and total femoral mineral density. Both oleuropein and olive oil prevented this bone loss in OVX rats with inflammation. At necropsy, oleuropein and olive oil consumption had had no effect on plasma osteocalcin concentrations (marker of bone formation) or on urinary deoxypyridinoline excretion (marker of bone resorption). In conclusion, oleuropein and olive-oil feeding can prevent inflammation-induced osteopenia in OVX rats.
Databáze: OpenAIRE
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