Inherited propensity for neuropathic pain is mediated by sensitivity to injury discharge
| Autor: | Sergiu Cohn, Zeʼev Seltzer |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Strain (injury) Peripheral Nerve Injuries Internal medicine medicine Animals Peripheral Nerves Selection Genetic Denervation business.industry General Neuroscience Neurectomy Nerve Block Rats Inbred Strains Nerve injury medicine.disease Sciatic Nerve Electric Stimulation Rats Endocrinology Neuropathic pain Neuralgia medicine.symptom business Autotomy Self-Injurious Behavior |
| Zdroj: | Neuroreport. 2(11) |
| ISSN: | 0959-4965 |
| Popis: | We reported previously that injury discharge (ID), a burst of impulses fired following nerve injury, plays a role in triggering autotomy, a neuropathic pain-related behavior in rats. Here we affirm this link using two lines of rats, derived by selective breeding from the Sabra strain to express high (HA) or low (LA) levels of autotomy following hindpaw denervation. Blocking ID in HA rats before injury suppressed autotomy. Correspondingly, artificial prolongation of ID in LA rats just prior to neurectomy, increased autotomy. The autotomy in these HA and LA rats was like that of their Sabra ancestors. This suggests that the underlying basis for selection of these lines was differential sensitivity of the CNS to the effects of ID. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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