Clinical Efficacy of Tumor Antigen-Pulsed DC Treatment for High-Grade Glioma Patients: Evidence from a Meta-Analysis
| Autor: | Min Wang, Jin-Long Liu, Bei-Lei Xu, Hai-Bo Wang, Jun-Xia Cao, Duo Li, Jun-Li Li, Yi-Shan Liu, Zheng-Xu Wang, Xiaoyan Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Oncology
Male medicine.medical_treatment Cancer Treatment lcsh:Medicine Immunophenotyping Cancer immunotherapy Animal Cells Medicine and Health Sciences lcsh:Science Multidisciplinary Brain Neoplasms Glioma Middle Aged Tumor antigen Treatment Outcome Cytokines Female Immunotherapy Cellular Types Research Article Tumor Immunology Adult medicine.medical_specialty Immune Cells Immunology Disease-Free Survival Immune system Antigens Neoplasm Internal medicine medicine Humans Survival analysis business.industry lcsh:R Immunity Biology and Life Sciences Cell Biology Dendritic Cells medicine.disease Survival Analysis Clinical trial lcsh:Q Clinical Immunology Neoplasm Grading business |
| Zdroj: | PLoS ONE PLoS ONE, Vol 9, Iss 9, p e107173 (2014) |
| ISSN: | 1932-6203 |
| Popis: | BACKGROUND:The effectiveness of immunotherapy for high-grade glioma (HGG) patients remains controversial. To evaluate the therapeutic efficacy of dendritic cells (DCs) alone in the treatment of HGG, we performed a systematic review and meta-analysis in terms of patient survival with relevant published clinical studies. MATERIALS AND METHODS:A total of 409 patients, including historical cohorts, nonrandomized and randomized controls with HGG, were selected for the meta-analysis. RESULTS:The treatment of HGG with DCs was associated with a significantly improved one-year survival (OS) (p0.05), whereas CD56+ lymphocyte subset were significantly increased after DC treatment (p = 0.0001). Furthermore, the levels of IFN-γ in the peripheral blood of HGG patients, which reflect the immune function of the patients, were significantly increased after DC immunotherapy (p |
| Databáze: | OpenAIRE |
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