Myelin water fraction decrease in individuals with chronic mild traumatic brain injury and persistent symptoms
Autor: | Naznin Virji-Babul, Irene M. Vavasour, William J. Panenka, Ivan J. Torres, Angela M. Muller, Alex L. MacKay, Victoria Purcell, Bretta Russell-Schulz, Leyla R. Brucar, Jing Zhang |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Science (General) Traumatic brain injury Splenium NIH Toolbox Corpus callosum White matter 03 medical and health sciences Q1-390 0302 clinical medicine Magnetic resonance imaging Cognition Myelin water fraction Internal medicine medicine Mild traumatic brain injury Chronic injury H1-99 Multidisciplinary medicine.diagnostic_test business.industry medicine.disease Social sciences (General) 030104 developmental biology medicine.anatomical_structure Corticospinal tract Cardiology business 030217 neurology & neurosurgery Research Article |
Zdroj: | Heliyon Heliyon, Vol 7, Iss 4, Pp e06709-(2021) |
ISSN: | 2405-8440 |
Popis: | The diffuse and continually evolving secondary changes after mild traumatic brain injury (mTBI) make it challenging to assess alterations in brain-behaviour relationships. In this study we used myelin water imaging to evaluate changes in myelin water fraction (MWF) in individuals with chronic mTBI and persistent symptoms and measured their cognitive status using the NIH Toolbox Cognitive Battery. Fifteen adults with mTBI with persistent symptoms and twelve age, gender and education matched healthy controls took part in this study. We found a significant decrease in global white matter MWF in patients compared to the healthy controls. Significantly lower MWF was evident in most white matter region of interest (ROIs) examined including the corpus callosum (separated into genu, body and splenium), minor forceps, right anterior thalamic radiation, left inferior longitudinal fasciculus; and right and left superior longitudinal fasciculus and corticospinal tract. Although patients showed lower cognitive functioning, no significant correlations were found between MWF and cognitive measures. These results suggest that individuals with chronic mTBI who have persistent symptoms have reduced MWF. magnetic resonance imaging; mild traumatic brain injury; cognition; myelin water fraction; chronic injury |
Databáze: | OpenAIRE |
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