Cadherins in Brain Morphogenesis and Wiring
| Autor: | Masatoshi Takeichi, Shinji Hirano |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Nervous system
Physiology Morphogenesis Biology Mice Physiology (medical) Cell Adhesion medicine Animals Humans Cell adhesion Molecular Biology Cell Proliferation Cell adhesion molecule Cadherin Cell growth Brain Cell Polarity Gene Expression Regulation Developmental General Medicine Cadherins Cell biology medicine.anatomical_structure Brain morphogenesis Neural development Neuroscience |
| Zdroj: | Physiological Reviews. 92:597-634 |
| ISSN: | 1522-1210 0031-9333 |
| Popis: | Cadherins are Ca2+-dependent cell-cell adhesion molecules that play critical roles in animal morphogenesis. Various cadherin-related molecules have also been identified, which show diverse functions, not only for the regulation of cell adhesion but also for that of cell proliferation and planar cell polarity. During the past decade, understanding of the roles of these molecules in the nervous system has significantly progressed. They are important not only for the development of the nervous system but also for its functions and, in turn, for neural disorders. In this review, we discuss the roles of cadherins and related molecules in neural development and function in the vertebrate brain. |
| Databáze: | OpenAIRE |
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