Serum complexed and free prostate specific antigen levels are lower in female elite athletes in comparison to control women
| Autor: | Eleftherios P. Diamandis, Yingye Zheng, Martin Stengelin, Eli N. Glezer, Carla M. J. Muytjens, Galina Nikolenko, Sarah E Wheeler, Anu Mathew, Emma Eklund, Angelica Lindén Hirschberg, Marshall D. Brown |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.drug_class Physiology Dehydroepiandrosterone Estrone prostate specific antigen General Biochemistry Genetics and Molecular Biology hyperandrogenism 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Medicine General Pharmacology Toxicology and Pharmaceutics Testosterone serum PSA in women fifth-generation PSA assays General Immunology and Microbiology business.industry Hyperandrogenism Reproductive Endocrinology & Infertility General Medicine Articles medicine.disease Androgen Prostate-specific antigen 030104 developmental biology Endocrinology chemistry Estrogen 030220 oncology & carcinogenesis Dihydrotestosterone Olympic teams elite female athletes business medicine.drug Research Article |
| Zdroj: | F1000Research |
| ISSN: | 2046-1402 |
| Popis: | Background: We hypothesize that prostate specific antigen (PSA), a protein that it is under regulation by androgens, may be differentially expressed in female elite athletes in comparison to control women.Methods: We conducted a cross-sectional study of 106 female athletes and 114 sedentary age-matched controls. Serum from these women was analyzed for complexed prostate specific antigen (cPSA) and free prostate specific antigen (fPSA), by fifth generation assays with limits of detection of around 6 and 140 fg/mL, respectively. A panel of estrogens, androgens and progesterone in the same serum was also quantified by tandem mass spectrometry. Results: Both components of serum PSA (cPSA and fPSA) were lower in the elite athletes vs the control group (P=0.033 and 0.013, respectively). Furthermore, estrone (p=0.003) and estradiol (p=0.004) were significantly lower, and dehydroepiandrosterone (p=0.095) and 5-androstene-3β, 17β-diol (p=0.084) tended to be higher in the athletes vs controls. Oral contraceptive use was similar between groups and significantly associated with increased cPSA and fPSA in athletes (p= 0.046 and 0.009, respectively). PSA fractions were not significantly associated with progesterone changes. The Spearman correlation between cPSA and fPSA in both athletes and controls was 0.75 (P < 0.0001) and 0.64 (P < 0.0001), respectively. Conclusions: Elite athletes have lower complexed and free PSA, higher levels of androgen precursors and lower levels of estrogen in their serum than sedentary control women.Abbreviations: cPSA, complexed PSA; fPSA, free PSA; PCOS, polycystic ovarian syndrome; E1, estrone; E2, estradiol; DHEA, dehydroepiandrosterone, Testo, testosterone; DHT, dihydrotestosterone; PROG, progesterone; Delta 4, androstenedione; Delta 5, androst-5-ene-3β, 17β-diol; BMD, body mineral density; LLOQ, lower limit of quantification; ULOQ, upper limit of quantification; LOD, limit of detection; ACT, α1-antichymotrypsin |
| Databáze: | OpenAIRE |
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