Lower limb muscle strength and serotonin receptor gene polymorphism as factors associated in women with fibromyalgia
| Autor: | Denilson de Castro Teixeira, Priscila Daniele de Oliveira Perrucini, Karen Barros Parron Fernandes, Layse Rafaela Moroti-Perugini, Luana Oliveira de Lima, Regina Célia Poli-Frederico, Carlos Alexandre Martins Zicarelli, Andressa Saori Matsumura |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
medicine.medical_specialty Fibromyalgia lcsh:Diseases of the musculoskeletal system Real-Time Polymerase Chain Reaction White People 03 medical and health sciences 0302 clinical medicine Rheumatology Polymorphism (computer science) Internal medicine Genotype medicine Genetic predisposition Humans Receptor Serotonin 5-HT2A Women 030212 general & internal medicine Allele Serotonin receptor HTR2A 030203 arthritis & rheumatology Sitting Position Chi-Square Distribution Polymorphism Genetic Genetic polymorphism business.industry Muscle strength Chronic pain Skeletal muscle Middle Aged medicine.disease medicine.anatomical_structure Lower Extremity Case-Control Studies Standing Position Female Gene polymorphism lcsh:RC925-935 business lcsh:RC581-607 |
| Zdroj: | Advances in Rheumatology, Vol 59, Iss 1, Pp 1-7 (2019) Advances in Rheumatology, Volume: 59, Article number: 59, Published: 13 JAN 2020 |
| ISSN: | 2523-3106 |
| Popis: | Background Fibromyalgia (FM) is a chronic pain syndrome characterized by generalized skeletal muscle chronic pain. Its etiology is not well defined, because there are several factors that may trigger it such as physical and/or emotional stresses, or a genetic susceptibility, involving serotonergic, dopaminergic and catecholaminergic paths. The objective of this study was to investigate the association between the strength of the lower limb, genetic polymorphism of the serotonin receptor gene HTR2A in women with fibromyalgia. Methods In this observational study of case-control type 48 women were evaluated who belonged to the group with FM (52 ± 12 years) and 100 women in the control group (58 ± 11 years). Socio demographic and anthropometric data were collected and peripheral blood samples for DNA extraction; genotypic analyzes were performed by means of PCR in real time by TaqMan® system. The lower limb muscle strength was assessed through the test of sitting down and standing up for 30 s. The chi-square test or Fischer Exact was used for possible associations among the variables; the t-test for independent samples was used to compare the averages among the groups; the value of significance adopted was 5%. Results There was an association between the polymorphism of the HTR2A gene with FM, demonstrating that carriers of the genotype GG have 24.39 times more likely to develop the syndrome (IC95% 5.15–115.47; p = 0.01). It was observed an association between FM and the test to sit and stand up demonstrating that women with fibromyalgia have lower limb muscle strength (p = 0.01). The study showed that the white race has 3.84 times more likely to develop FM (p = 0.01). Conclusion The results of this study suggest that women of Caucasian ethnicity with GG genotype or G allele presented greater risk of developing fibromyalgia and that these patients have lower limb muscle strength compared to the control group. |
| Databáze: | OpenAIRE |
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