Nicotinic Acetylcholine Receptor beta 2 Subunits in the Medial Prefrontal Cortex Control Attention
| Autor: | Sabine Spijker, Huibert D. Mansvelder, Bernard Bloem, Maarten Loos, Karine Guillem, Uwe Maskos, August B. Smit, Rogier B. Poorthuis |
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| Přispěvatelé: | Center for Neurogenomics and Cognitive Research [Amsterdam, Pays-Bas] (CNCR), Vrije Universiteit Amsterdam [Amsterdam] (VU), Neurobiologie Intégrative des Systèmes Cholinergiques (NISC), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), U.M. and A.B.S. received funding from the EU Seventh Framework Programme 'Neurocypres' (HEALTH-F2-2007-202088), H.D.M., from the Netherlands Organization for Scientific Research (917.76.360 and 912.06.148), Neurobasic PharmaPhenomics, and the VU University board., We thank J. Staal and H. Lodder., European Project: 202088,EC:FP7:HEALTH,FP7-HEALTH-2007-A,NEUROCYPRES(2008), Integrative Neurophysiology, Molecular and Cellular Neurobiology, AIMMS, Neuroscience Campus Amsterdam - Attention & Cognition, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
Patch-Clamp Techniques Prefrontal Cortex Stimulation Receptors Nicotinic Mice 03 medical and health sciences Cognition 0302 clinical medicine Transduction Genetic Reaction Time Animals Medicine Attention Effects of sleep deprivation on cognitive performance Prefrontal cortex 030304 developmental biology Acetylcholine receptor Mice Knockout Neurons Motivation 0303 health sciences Multidisciplinary Behavior Animal [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior business.industry Acetylcholine Nicotinic acetylcholine receptor Nicotinic agonist nervous system Cholinergic business Neuroscience Gene Deletion 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Science; Vol 333 Science Science, 2011, 333 (6044), pp.888-891. ⟨10.1126/science.1207079⟩ Science, 333, 888-891. American Association for the Advancement of Science Guillem, K, Bloem, B, Poorthuis, R B, Loos, M, Smit, A B, Maskos, U, Spijker, S & Mansvelder, H D 2011, ' Nicotinic acetylcholine receptor β2-subunits in the medial prefrontal cortex control attention ', Science, vol. 333, pp. 888-891 . https://doi.org/10.1126/science.1207079 Science, American Association for the Advancement of Science, 2011, 333 (6044), pp.888-891. ⟨10.1126/science.1207079⟩ |
| ISSN: | 0036-8075 1095-9203 |
| DOI: | 10.1126/science.1207079 |
| Popis: | International audience; More than one-third of all people are estimated to experience mild to severe cognitive impairment as they age. Acetylcholine (ACh) levels in the brain diminish with aging, and nicotinic ACh receptor (nAChR) stimulation is known to enhance cognitive performance. The prefrontal cortex (PFC) is involved in a range of cognitive functions and is thought to mediate attentional focus. We found that mice carrying nAChR β2-subunit deletions have impaired attention performance. Efficient lentiviral vector-mediated reexpression of functional β2-subunit-containing nAChRs in PFC neurons of the prelimbic area (PrL) completely restored the attentional deficit but did not affect impulsive and motivational behavior. Our findings show that β2-subunit expression in the PrL PFC is sufficient for endogenous nAChR-mediated cholinergic regulation of attentional performance. |
| Databáze: | OpenAIRE |
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