Effects of alcohol dependence on discrete choice between alcohol and saccharin
| Autor: | Douglas Funk, Anh D. Lê, Andrew Loughlin, Melissa Russo, Kathleen M. Coen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Drug Nicotine medicine.medical_specialty media_common.quotation_subject Self Administration Alcohol Choice Behavior Article Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Saccharin 0302 clinical medicine Internal medicine medicine Animals Rats Long-Evans Nicotinic Agonists media_common Pharmacology Discrete choice Quinine Ethanol business.industry Alcohol dependence Central Nervous System Depressants 030227 psychiatry Alcoholism Psychiatry and Mental health Endocrinology chemistry Self-administration business psychological phenomena and processes 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neuropsychopharmacology. 43:1859-1866 |
| ISSN: | 1740-634X 0893-133X |
| DOI: | 10.1038/s41386-018-0101-1 |
| Popis: | Dependence on drugs has enduring effects on drug intake and relapse. The role of choice in enhanced susceptibility to drug use in drug dependence has been little studied. Here we determine the effects of alcohol dependence on the choice between alcohol and a non-drug reward, saccharin, using the discrete choice model in food-restricted male rats. We trained rats to self-administer alcohol (12% w/v) and saccharin (0.05, 0.1%), tested their choice of alcohol vs. saccharin, and determined the effects of deprivation and intertrial interval (ITI) duration on choice. We then determined the effects of alcohol dependence, induced by repeated intermittent exposure to alcohol vapor on choice of alcohol vs. saccharin (0.1%) in discrete choice trials as well as on the effects of adulteration of alcohol with quinine on choice. We trained another group of rats to self-administer intravenous (i.v.) nicotine (0.03 mg/kg/infusion) and oral saccharin (0.1%), determined their choice, and examined the roles of ITI duration and concurrent access on choice. Rats chose equivalent amounts of 0.05% saccharin and 12% alcohol, showed a stronger choice for 0.1% saccharin, and alcohol and saccharin choice were modestly decreased and increased, respectively, by deprivation. Alcohol dependence led to profound increases in the choice of alcohol over saccharin while adulteration of alcohol with quinine did not affect choice in non-dependent or dependent rats. Rats showed marked choice for 0.1% saccharin over i.v. nicotine. The strong effect that dependence had on alcohol choice is an important validation of the discrete choice procedure. |
| Databáze: | OpenAIRE |
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