Efficacy, biocompatibility and degradability of carbon nanoparticles for photothermal therapy of lung cancer
| Autor: | Kokalari, Ida, Keshavan, Sandeep, Rahman, Mizanur, Gazzano, Elena, Barzan, Giulia, Mandrile, Luisa, Giovannozzi, Andrea, Ponti, Jessica, Antonello, Giulia, Monopoli, Marco, Perrone, Guido, Bergamaschi, Enrico, Riganti, Chiara, Fadeel, Bengt, Fenoglio, Ivana |
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| Rok vydání: | 2021 |
| Předmět: |
Programmed cell death
Lung Neoplasms photothermal therapy Biocompatibility DNA damage biodegradation carbon-based nanomaterials immune cells lung cancer Biomedical Engineering Medicine (miscellaneous) Bioengineering 02 engineering and technology Development 03 medical and health sciences Immune system Cell Line Tumor Heat shock protein medicine Humans General Materials Science Lung cancer 030304 developmental biology 0303 health sciences Chemistry Photothermal therapy 021001 nanoscience & nanotechnology medicine.disease Carbon 3. Good health A549 Cells Cancer research Nanoparticles 0210 nano-technology Phototoxicity |
| Zdroj: | Nanomedicine. 16:689-707 |
| ISSN: | 1748-6963 1743-5889 |
| Popis: | Aim: To investigate near infrared-induced phototoxicity toward lung cancer cells, and the biodegradability and effect on immune cells of glucose-derived carbon nanoparticles (CNPs). Methods: The human A549 lung adenocarcinoma cell line was used as a model to study the phototoxicity of CNPs. The biodegradability and the effect on immune cells was demonstrated in primary human neutrophils and macrophages. Results: Near infrared-activated CNPs elicited rapid cell death, characterized by the elevation of heat shock proteins and the induction of DNA damage. CNPs were found to be noncytotoxic toward primary human macrophages and were susceptible to biodegradation when cocultured with human neutrophils. Conclusions: Our results identify CNPs as promising platforms for photothermal therapy of lung cancer. |
| Databáze: | OpenAIRE |
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