The importance of CDC27 in cancer: molecular pathology and clinical aspects
| Autor: | Nazanin Atieh Kazemi-Sefat, Kazem Mousavizadeh, Roya Sajed, Kaveh Kavousi, Golnaz Ensieh Kazemi-Sefat, Mohammad Keramatipour, Saeed Talebi |
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| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Tumor suppressor gene Review Cell cycle Biology medicine.disease_cause lcsh:RC254-282 Metastasis 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Cancer stem cell Neoplasms Upregulation Genetics medicine lcsh:QH573-671 CDC27 protein 030304 developmental biology Anaphase-Promoting complex–cyclosome 0303 health sciences lcsh:Cytology Cancer lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Oncology 030220 oncology & carcinogenesis Downregulation Tumorigenesis Cancer cell Cancer research Carcinogenesis |
| Zdroj: | Cancer Cell International Cancer Cell International, Vol 21, Iss 1, Pp 1-11 (2021) |
| ISSN: | 1475-2867 |
| Popis: | BackgroundCDC27 is one of the core components of Anaphase Promoting complex/cyclosome. The main role of this protein is defined at cellular division to control cell cycle transitions. Here we review the molecular aspects that may affect CDC27 regulation from cell cycle and mitosis to cancer pathogenesis and prognosis.Main textIt has been suggested that CDC27 may play either like a tumor suppressor gene or oncogene in different neoplasms. Divergent variations inCDC27DNA sequence and alterations in transcription ofCDC27have been detected in different solid tumors and hematological malignancies. ElevatedCDC27expression level may increase cell proliferation, invasiveness and metastasis in some malignancies. It has been proposed thatCDC27upregulation may increase stemness in cancer stem cells. On the other hand, downregulation ofCDC27may increase the cancer cell survival, decrease radiosensitivity and increase chemoresistancy. In addition,CDC27downregulation may stimulate efferocytosis and improve tumor microenvironment.ConclusionCDC27 dysregulation, either increased or decreased activity, may aggravate neoplasms. CDC27 may be suggested as a prognostic biomarker in different malignancies. |
| Databáze: | OpenAIRE |
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